Evidence map›Paper›PMID 11731568›Full record

ReviewThe Journal of physiology2001

Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications.

U Proske, D L Morgan

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07728422 (Effects of Ozone Therapy Modalities on Biochemical Markers of Muscle Damage Following Eccentric Exercise), which is not on this map. Cited by 484 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
484citing papers in PubMed, 22 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07728422 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Ozone Therapy Modalities on Biochemical Markers of Muscle Damage Following Eccentric Exercise

TypeinterventionalSponsorInonu UniversityRan2024 to 2025Enrolled32ConditionsOzone Therapy, Muscle Damage, Oxidative Stress, RecoveryArmsAutohemotherapy, Ozone Sauna Therapy, Ozonated Lavender Oil Massage
3 · Its place in the literature

Who cites it

484 citing papers in PubMed, 22 syntheses or guidelines pooled it.

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  19. Chronic Adaptations to Eccentric Cycling Training: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023
    Pooled it
  20. Coenzyme QNutrients · 2022
    Pooled it

424 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

U ProskeDepartment of Physiology, Monash University, Melbourne, Victoria, Australia. uwe.proske@med.monash.edu.au
D L Morgan

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In eccentric exercise the contracting muscle is forcibly lengthened; in concentric exercise it shortens. While concentric contractions initiate movements, eccentric contractions slow or stop them. A unique feature of eccentric exercise is that untrained subjects become stiff and sore the day afterwards because of damage to muscle fibres. This review considers two possible initial events as responsible for the subsequent damage, damage to the excitation-contraction coupling system and disruption at the level of the sarcomeres. Other changes seen after eccentric exercise, a fall in active tension, shift in optimum length for active tension, and rise in passive tension, are seen, on balance, to favour sarcomere disruption as the starting point for the damage. As well as damage to muscle fibres there is evidence of disturbance of muscle sense organs and of proprioception. A second period of exercise, a week after the first, produces much less damage. This is the result of an adaptation process. One proposed mechanism for the adaptation is an increase in sarcomere number in muscle fibres. This leads to a secondary shift in the muscle's optimum length for active tension. The ability of muscle to rapidly adapt following the damage from eccentric exercise raises the possibility of clinical applications of mild eccentric exercise, such as for protecting a muscle against more major injuries.

Indexed as

Adaptation, PhysiologicalAnimalsBiomechanical PhenomenaEdemaExerciseHumansMechanoreceptorsMuscle ContractionMuscle, SkeletalMuscle SpindlesMuscular DiseasesPain

Identifiers

PMID11731568
PMCPMC2278966

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.