ArticleGenome research2001
Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- The SHR/Akr Y chromosome reveals repeated turnover of the rat pseudoautosomal region.bioRxiv : the preprint server for biology · 2025Article
- shox2 is required for vestibular statoacoustic neuron development.Biology open · 2022Article
- X-chromosome regulation and sex differences in brain anatomy.Neuroscience and biobehavioral reviews · 2021Review
- A strategic research alliance: Turner syndrome and sex differences.American journal of medical genetics. Part C, Seminars in medical genetics · 2019Review
- Genetic Diversity on the Human X Chromosome Does Not Support a Strict Pseudoautosomal Boundary.Genetics · 2016Article
- Human active X-specific DNA methylation events showing stability across time and tissues.European journal of human genetics : EJHG · 2014Article
- Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.Genetics · 2014Article
- Choline kinase beta is required for normal endochondral bone formation.Biochimica et biophysica acta · 2014Article
- Recombination in the human Pseudoautosomal region PAR1.PLoS genetics · 2014Article
- The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome.BMC genomics · 2008Article
- The Human Pseudoautosomal Region (PAR): Origin, Function and Future.Current genomics · 2007Article
- A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Creation of non-human primate neurogenetic disease models by gene targeting and nuclear transfer.Reproductive biology and endocrinology : RB&E · 2004Review
- Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Complex events in the evolution of the human pseudoautosomal region 2 (PAR2).Genome research · 2003Article
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Authors and funding
10 authors at 1 institution in 4 countries.
Funding
Abstract
The human pseudoautosomal region 1 (PAR1) is essential for meiotic pairing and recombination, and its deletion causes male sterility. Comparative studies of human and mouse pseudoautosomal genes are valuable in charting the evolution of this interesting region, but have been limited by the paucity of genes conserved between the two species. We have cloned a novel human PAR1 gene, DHRSXY, encoding an oxidoreductase of the short-chain dehydrogenase/reductase family, and isolated a mouse ortholog Dhrsxy. We also searched for mouse homologs of recently reported PGPL and TRAMP genes that flank it within PAR1. We recovered a highly conserved mouse ortholog of PGPL by cross-hybridization, but found no mouse homolog of TRAMP. Like Csf2ra and Il3ra, both mouse homologs are autosomal; Pgpl on chromosome 5, and Dhrsxy subtelomeric on chromosome 4. TRAMP, like the human genes within or near PAR1, is probably very divergent or absent in the mouse genome. We interpret the rapid divergence and loss of pseudoautosomal genes in terms of a model of selection for the concentration of repetitive recombinogenic sequences that predispose to high recombination and translocation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.