ArticleAnnals of surgery2001
Identification of disease-specific genes in chronic pancreatitis using DNA array technology.
Article in Annals of surgery, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Meta-analysis of microarray data on pancreatic cancer defines a set of commonly dysregulated genes.Oncogene · 2005Pooled it
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- Increased SPARC expression is associated with neoadjuvant therapy in resectable pancreatic ductal adenocarcinoma.Practical laboratory medicine · 2020Article
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- Smad4 loss synergizes with TGFα overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis.PloS one · 2015Article
- What is personalized medicine and what should it replace?Nature reviews. Gastroenterology & hepatology · 2012Review
- Unraveling the mystery of pain in chronic pancreatitis.Nature reviews. Gastroenterology & hepatology · 2012Review
- Proteomic analysis of a rat pancreatic stellate cell line using liquid chromatography tandem mass spectrometry (LC-MS/MS).Journal of proteomics · 2011Article
- Poly(A) RT-PCR measurement of diagnostic genes in pancreatic juice in pancreatic cancer.British journal of cancer · 2011Article
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- Endometrial cysteine-rich secretory protein 3 is inhibited by human chorionic gonadotrophin, and is increased in the decidua of tubal ectopic pregnancy.Molecular human reproduction · 2009Article
- Northern blot analysis for detection and quantification of RNA in pancreatic cancer cells and tissues.Nature protocols · 2009Article
- Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit trigeminal ganglia.Molecular vision · 2008Article
- Transcriptional network governing the angiogenic switch in human pancreatic cancer.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2007Article
- Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer.Molecular cancer · 2005Article
- Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives.International journal of colorectal disease · 2004Review
- Expression and functional significance of CDC25B in human pancreatic ductal adenocarcinoma.Oncogene · 2004Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo use DNA arrays to analyze the differential gene expression patterns in the normal pancreas and in pancreatic diseases. SUMMARY BACKGROUND DATA: Genome-wide gene expression analysis will provide new insights into gene function and cause of disease.
methodsRNA was extracted from eight normal pancreatic specimens, eight specimens with chronic pancreatitis (CP), and eight pancreatic cancer (PCa) tissues. Poly A(+) RNA was purified, reverse-transcribed, and converted into cRNA using biotinylated nucleotides. The HuGeneFL DNA array containing 5,600 full-length human genes was used for analysis.
resultsFirst, normal pancreatic tissues were analyzed in comparison with a panel of other normal tissues (colon, liver, prostate, lung, lymph node). This analysis revealed 11 signature genes that were selectively expressed in the pancreas (e.g., pancreatic elastase-IIA). Comparison of the expression of 5,600 genes between the normal pancreas, CP, and PCa specimens showed that the expression of 34 genes was decreased in CP tissues compared with normal pancreatic tissues, and that the expression of all of these genes was simultaneously decreased in PCa. In addition, the expression of 157 genes was increased in CP tissues compared with the normal pancreas. Of those, 152 genes were simultaneously increased in PCa. Thus, only 5 of 5,600 genes were significantly overexpressed in CP compared with both normal pancreas and PCa.
conclusionsThe majority of alterations observed in CP are present in PCa, and the number of genes whose expression is selectively deregulated in CP is surprisingly small. These results may provide new insight into the pathobiology of CP and help identify certain molecular alterations that might serve as targets for new diagnostic tools and disease-specific therapy.
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