ArticleGenetics2001
Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed.
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- Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Association ofF1000Research · 2022Article
- Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.Nature communications · 2020Article
- The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study.Pediatric allergy, immunology, and pulmonology · 2019Article
- Modeling Heterogeneity in the Genetic Architecture of Ethnically Diverse Groups Using Random Effect Interaction Models.Genetics · 2019Article
- Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture.BMC genomics · 2015Article
- Systemic lupus erythematosus-associated neutrophil cytosolic factor 2 mutation affects the structure of NADPH oxidase complex.The Journal of biological chemistry · 2015Article
- GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.Genes and immunity · 2014Article
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- Inherited susceptibility to chronic lymphocytic leukemia: evidence and prospects for the future.Therapeutic advances in hematology · 2013Article
- Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis.Age (Dordrecht, Netherlands) · 2012Article
- Genome-wide pathway association studies of multiple correlated quantitative phenotypes using principle component analyses.PloS one · 2012Article
- SHIPS: Spectral Hierarchical clustering for the Inference of Population Structure in genetic studies.PloS one · 2012Article
- Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients.Age (Dordrecht, Netherlands) · 2011Article
- No association between polymorphisms and haplotypes of COL1A1 and COL1A2 genes and osteoporotic fracture in postmenopausal Chinese women.Acta pharmacologica Sinica · 2011Article
- Tuberculosis as a complex trait: impact of genetic epidemiological study design.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Genetic epidemiology of tuberculosis susceptibility: impact of study design.PLoS pathogens · 2011Review
- Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.BMC medical genomics · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Association studies using random population samples are increasingly being applied in the identification and inference of genetic effects of genes underlying complex traits. It is well recognized that population admixture may yield false-positive identification of genetic effects for complex traits. However, it is less well appreciated that population admixture can appear to mask, change, or reverse true genetic effects for genes underlying complex traits. By employing a simple population genetics model, we explore the effects and the conditions of population admixture in masking, changing, or even reversing true genetic effects of genes underlying complex traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.