ArticleThe EMBO journal2001
Control of branch-site choice by a group II intron.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Recurrent Modular Assembly Drives Independent Origins of Group II Introns Encoding LAGLIDADG Homing Endonucleases.Genome biology and evolution · 2026Article
- Structural basis of branching during RNA splicing.Nature structural & molecular biology · 2024Article
- Article
- Activating the branch-forming splicing pathway by reengineering the ribozyme component of a natural group II intron.RNA (New York, N.Y.) · 2016Article
- Now on display: a gallery of group II intron structures at different stages of catalysis.Mobile DNA · 2013Article
- Relevance of the branch point adenosine, coordination loop, and 3' exon binding site for in vivo excision of the Sinorhizobium meliloti group II intron RmInt1.The Journal of biological chemistry · 2011Article
- The tertiary structure of group II introns: implications for biological function and evolution.Critical reviews in biochemistry and molecular biology · 2010Review
- A cytoplasmically inherited barley mutant is defective in photosystem I assembly due to a temperature-sensitive defect in ycf3 splicing.Plant physiology · 2009Article
- Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast.Molecular cell · 2009Article
- The linear form of a group II intron catalyzes efficient autocatalytic reverse splicing, establishing a potential for mobility.RNA (New York, N.Y.) · 2009Article
- Group II intron in Bacillus cereus has an unusual 3' extension and splices 56 nucleotides downstream of the predicted site.Nucleic acids research · 2007Article
- Multiple physical forms of excised group II intron RNAs in wheat mitochondria.Nucleic acids research · 2006Article
- Zn2+-dependent deoxyribozymes that form natural and unnatural RNA linkages.Biochemistry · 2005Article
- In vitro selection, characterization, and application of deoxyribozymes that cleave RNA.Nucleic acids research · 2005Review
- A deoxyribozyme that synthesizes 2',5'-branched RNA with any branch-site nucleotide.Nucleic acids research · 2005Article
- A conjugation-based system for genetic analysis of group II intron splicing in Lactococcus lactis.Journal of bacteriology · 2004Article
- Mutations in the Lactococcus lactis Ll.LtrB group II intron that retain mobility in vivo.BMC molecular biology · 2002Article
- Lariat formation and a hydrolytic pathway in plant chloroplast group II intron splicing.The EMBO journal · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The branch site of group II introns is typically a bulged adenosine near the 3'-end of intron domain 6. The branch site is chosen with extraordinarily high fidelity, even when the adenosine is mutated to other bases or if the typically bulged adenosine is paired. Given these facts, it has been difficult to discern the mechanism by which the proper branch site is chosen. In order to dissect the determinants for branch-point recognition, new mutations were introduced in the vicinity of the branch site and surrounding domains. Single mutations did not alter the high fidelity for proper branch-site selection. However, several combinations of mutations moved the branch site systematically to new positions along the domain 6 stem. Analysis of those mutants, together with a new alignment of domain 5 and domain 6 sequences, reveals a set of structural determinants that appear to govern branch-site selection by group II introns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.