ArticleProceedings of the National Academy of Sciences of the United States of America2001
Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed.
- Identification and quantification of irreversibility in stochastic systems.Physical chemistry chemical physics : PCCP · 2026Review
- Transiently amplified fluctuations assemble dissipative materials.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Electrical Control of the Transduction Channels' Gating Force in Mechanosensory Hair Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stochastic motility energetics reveals cooperative bacterial swarming in optical tweezers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Motorized chromosome models of mitotic chromosome folding.Nature communications · 2025Article
- A mosquito-inspired theoretical framework for acoustic signal detection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Amplification through local critical behavior in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Critical Thing about the Ear's Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Neural control and innate self-tuning of the hair cell's active process.Biophysical journal · 2024Article
- Time-reversal symmetry breaking in the chemosensory array reveals a general mechanism for dissipation-enhanced cooperative sensing.Nature communications · 2024Article
- Accessing activity and viscoelastic properties of artificial and living systems from passive measurement.Nature materials · 2024Article
- Criticality and chaos in auditory and vestibular sensing.Scientific reports · 2024Article
- Review of chaos in hair-cell dynamics.Frontiers in neurology · 2024Review
- Active oscillations in microscale navigation.Animal cognition · 2023Review
- Studying fluctuating trajectories of optically confined passive tracers inside cells provides familiar active forces.Biomedical optics express · 2023Article
- Vestibular Drop Attacks and Meniere's Disease as Results of Otolithic Membrane Damage-A Numerical Model.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Inferring entropy production rate from partially observed Langevin dynamics under coarse-graining.Physical chemistry chemical physics : PCCP · 2022Article
- Unloading outer hair cell bundles in vivo does not yield evidence of spontaneous oscillations in the mouse cochlea.Hearing research · 2022Article
- Whistling While it Works: Spontaneous Otoacoustic Emissions and the Cochlear Amplifier.Journal of the Association for Research in Otolaryngology : JARO · 2022Review
- Algorithmic Approaches for Assessing Irreversibility in Time Series: Review and Comparison.Entropy (Basel, Switzerland) · 2021Article
30 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
Hearing relies on active filtering to achieve exquisite sensitivity and sharp frequency selectivity. In a quiet environment, the ears of many vertebrates become unstable and emit one to several tones. These spontaneous otoacoustic emissions, the most striking manifestation of the inner ear's active process, must result from self-sustained mechanical oscillations of aural constituents. The mechanoreceptive hair bundles of hair cells in the bullfrog's sacculus have the ability to amplify mechanical stimuli and oscillate spontaneously. By comparing a hair bundle's spontaneous oscillations with its response to small mechanical stimuli, we demonstrate a breakdown in a general principle of equilibrium thermodynamics, the fluctuation-dissipation theorem. We thus confirm that a hair bundle's spontaneous movements are produced by energy-consuming elements within the hair cell. To characterize the dynamical behavior of the active process, we introduce an effective temperature that, for each frequency component, quantifies a hair bundle's deviation from thermal equilibrium. The effective temperature diverges near the bundle's frequency of spontaneous oscillation. This behavior, which is not generic for active oscillators, can be accommodated by a simple model that characterizes quantitatively the fluctuations of the spontaneous movements as well as the hair bundle's linear response function.
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