ArticleProceedings of the National Academy of Sciences of the United States of America2001
High frequency mitotic gene conversion in genetic hybrids of the oomycete Phytophthora sojae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 94 citations in OpenAlex.
- Host range expansion of asexual parasite can be explained by loss of adaptions in Muller's Ratchet.Nature communications · 2025Article
- Pathogenicity and virulence ofVirulence · 2025Review
- Recombination landscape and karyotypic variations revealed by linkage mapping in the grapevine downy mildew pathogen Plasmopara viticola.G3 (Bethesda, Md.) · 2025Article
- Unzipped chromosome-level genomes reveal allopolyploid nematode origin pattern as unreduced gamete hybridization.Nature communications · 2023Article
- Tightly linked Rps12 and Rps13 genes provide broad-spectrum Phytophthora resistance in soybean.Scientific reports · 2021Article
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- Comparative Genomics of Apomictic Root-Knot Nematodes: Hybridization, Ploidy, and Dynamic Genome Change.Genome biology and evolution · 2017Article
- Temporal Genetic Dynamics of an Experimental, Biparental Field Population ofFrontiers in genetics · 2017Article
- Escaping Host Immunity: New Tricks for Plant Pathogens.PLoS pathogens · 2016Review
- Genomic Characterization of a South American Phytophthora Hybrid Mandates Reassessment of the Geographic Origins of Phytophthora infestans.Molecular biology and evolution · 2016Article
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- The Top 10 oomycete pathogens in molecular plant pathology.Molecular plant pathology · 2015Review
- Sequence diversity in the large subunit of RNA polymerase I contributes to Mefenoxam insensitivity in Phytophthora infestans.Molecular plant pathology · 2014Article
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- Genetic diversity of Phytophthora colocasiae isolates in India based on AFLP analysis.3 Biotech · 2013Article
- Distinctive expansion of potential virulence genes in the genome of the oomycete fish pathogen Saprolegnia parasitica.PLoS genetics · 2013Article
- Article
- Dynamics and innovations within oomycete genomes: insights into biology, pathology, and evolution.Eukaryotic cell · 2012Review
- Genome sequencing and mapping reveal loss of heterozygosity as a mechanism for rapid adaptation in the vegetable pathogen Phytophthora capsici.Molecular plant-microbe interactions : MPMI · 2012Article
- Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Microbial populations depend on genetic variation to respond to novel environmental challenges. Plant pathogens are notorious for their ability to overcome pesticides and host resistance genes as a result of genetic changes. We report here that in particular hybrid strains of Phytophthora sojae, an oomycete pathogen of soybean, high frequency mitotic gene conversion rapidly converts heterozygous loci to homozygosity, resulting in heterokaryons containing highly diverse populations of diploid nuclei. In hybrids involving strain P7076, conversion rates of up to 3 x 10(-2) per locus per nucleus per generation were observed. In other hybrids, rates were of the order of 5 x 10(-5). Independent gene conversion was observed within a selected linkage group including loci as close as 0.7 kb apart and in unlinked markers throughout the genome. Gene conversions continued throughout vegetative growth and were stimulated by further sexual reproduction. At many loci, conversion showed extreme disparity, with one allele always being lost, suggesting that conversion was initiated by allele-specific double-stranded breaks. Pedigree analysis indicated that individual loci undergo multiple independent conversions within the nuclei of a vegetative clone and that conversion may be preceded by a heritable "activation" state.
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