Evidence map›Paper›PMID 11724912›Full record

ReviewMolecular pathology : MP2001

Guillain Barré syndrome.

J B Winer

Abstract readReview
In one paragraph

Review in Molecular pathology : MP, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 125 citations in OpenAlex.

  1. Article
  2. Neurolymphomatosis mimicking a Guillain-Barré syndrome triggered by COVID-19 vaccination.Neuropathology : official journal of the Japanese Society of Neuropathology · 2025
    Article
  3. Review
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  6. Review
  7. Is there a difference between GBS triggered by COVID-19 and those of other origins?The Egyptian journal of neurology, psychiatry and neurosurgery · 2022
    Article
  8. Guillain-Barré Syndrome in a Patient with Sickle Cell Anemia.HCA healthcare journal of medicine · 2021
    Article
  9. Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

J B WinerDepartment of Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK. j.b.winer@bham.ac.uk
Queen Elizabeth Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guillain Barré syndrome is one of the best examples of a post infectious immune disease and offers insights into the mechanism of tissue damage in other more common autoimmune diseases. Controlled epidemiological studies have linked it to infection with Campylobacter jejuni in addition to other viruses including cytomegalovirus and Epstein Barr virus. The syndrome includes several pathological subtypes, of which the most common is a multifocal demyelinating disorder of the peripheral nerves in close association with macrophages. Evidence from histological examination of peripheral nerve biopsy and postmortem samples suggests that both cell mediated and humoral mechanisms are involved in the pathogenesis. Immunological studies suggest that at least one third of patients have antibodies against nerve gangliosides, which in some cases also react with constituents of the liposaccharide of C jejuni. In the Miller Fisher variant of the disease, these antiganglioside antibodies have been shown to produce neuromuscular block, and may in part explain the clinical signs of that disorder. Treatment with both intravenous immunoglobulin and plasma exchange reduces the time taken for recovery to occur, although mortality remains around 8%, with about 20% of patients remaining disabled.

Indexed as

Guillain-Barre SyndromeAutoantibodiesAxonsBacterial InfectionsElectrophysiologyFemaleGangliosidesGlucocorticoidsHumansImmunoglobulins, IntravenousLymphocytesMacrophagesMaleNeuromuscular JunctionPlasma ExchangePrognosisAutoantibodiesGangliosidesGlucocorticoidsGQ1b gangliosideImmunoglobulins, Intravenous

Identifiers

PMID11724912
PMCPMC1187127
OpenAlexW1908861562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.