ArticleJournal of clinical microbiology2001
Molecular characterization of new clinical isolates of Candida albicans and C. dubliniensis in Japan: analysis reveals a new genotype of C. albicans with group I intron.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed.
- Exploring the Genetic Diversity of Candida albicans in Animal Hosts: A One Health Perspective.Zoonoses and public health · 2026Article
- Anti-Fungal and Toxicology Assessment of ISFP10, an Inhibitor of Fungal Phosphoglucomutase (PGM).Drugs in R&D · 2026Article
- Mating type and genotyping ofIranian journal of microbiology · 2026Article
- Phenotypic and genotypic characterization ofJournal of oral microbiology · 2025Article
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- Genotyping ofCurrent medical mycology · 2022Article
- Candida dubliniensis fungemia in a patient with severe COVID-19: A case report.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022Article
- Co-Infection of OralMedicina (Kaunas, Lithuania) · 2022Article
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- The genotypes and virulence attributes of C. albicans isolates from oral leukoplakia.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Evaluation of potentially probiotic attributes of certain dairy yeast isolated from buffalo sweetened Karish cheese.Heliyon · 2019Article
- Genotype Analysis of ClinicalInfection and drug resistance · 2019Article
- Semi-industrial Scale Production of a New Yeast with Probiotic Traits, Cryptococcus sp. YMHS, Isolated from the Red Sea.Probiotics and antimicrobial proteins · 2018Article
- Enterogenous infection ofWorld journal of emergency medicine · 2016Article
- Genotypic diversity and cariogenicity of Candida albicans from children with early childhood caries and caries-free children.BMC oral health · 2015Article
- Article
- Repetitive sequences based on genotyping of Candida albicans isolates obtained from Iranian patients with human immunodeficiency virus.Iranian journal of basic medical sciences · 2014Article
- Role of Candida albicans-secreted aspartyl proteinases (Saps) in severe early childhood caries.International journal of molecular sciences · 2014Article
- Development of a singleplex PCR assay for rapid identification and differentiation of Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. neoformans, Cryptococcus gattii, and hybrids.Journal of clinical microbiology · 2013Article
- Investigation of extracellular phospholipase and proteinase activities of Candida species isolated from individuals denture wearers and genotypic distribution of Candida albicans strains.Current microbiology · 2011Article
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No grant is acknowledged in the PubMed record.
Abstract
The genetic diversity of recent clinical isolates of Candida albicans in Japan was studied on the basis of amplified DNA band lengths determined with a specific PCR primer reported to have been designed to span a transposable intron region in the 25S rRNA gene. Our analyses of 301 clinical isolates of C. albicans showed that they could be classified into five genotypes: genotype A (172 isolates), genotype B (66 isolates), genotype C (56 isolates), genotype D (C. dubliniensis; 5 isolates), and a new genotype (designated genotype E; 2 isolates). The new genotype E was characterized to have a group I intron-like sequence, which is longer than hitherto reported ones and which has a nucleotide sequence length of 962 bp. Our analysis of the 962-bp sequence indicated that it is composed of an intron similar to that of C. dubliniensis of 621 bp with a 341-bp insertion. Analysis of the sequence of the internal transcribed spacer (ITS) region of the genotype E strain showed that its sequence is identical to those of strains of other genotypes, with only a few base substitution differences. Throughout the study, the possible horizontal transfer of the group I intron between C. dubliniensis and C. albicans was suggested. A high degree of correlation between the presence of a group I intron in C. albicans genotype E and susceptibility to the antifungal agent flucytosine was observed. The five isolates of C. dubliniensis examined in the present study showed genetic diversity when they were compared by randomly amplified polymorphic DNA fingerprinting pattern analysis, and this diversity was also confirmed by the analysis of ITS region sequences.
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