ArticleThe Journal of cell biology2001
Synchronized activation and refolding of influenza hemagglutinin in multimeric fusion machines.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity.Current opinion in structural biology · 2022Review
- Computational methods to study enveloped viral entry.Biochemical Society transactions · 2021Review
- Article
- Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers.Cell · 2018Article
- Capture and characterization of influenza A virus from primary samples using glycan bead arrays.Virology · 2016Article
- Notable Aspects of Glycan-Protein Interactions.Biomolecules · 2015Review
- Modifications of cysteine residues in the transmembrane and cytoplasmic domains of a recombinant hemagglutinin protein prevent cross-linked multimer formation and potency loss.BMC biotechnology · 2014Article
- Structural characterization of a fusion glycoprotein from a retrovirus that undergoes a hybrid 2-step entry mechanism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- The transmembrane domain and acidic lipid flip-flop regulates voltage-dependent fusion mediated by class II and III viral proteins.PloS one · 2013Article
- Influenza virus-membrane fusion triggered by proton uncaging for single particle studies of fusion kinetics.Analytical chemistry · 2012Article
- Review
- Intracellular curvature-generating proteins in cell-to-cell fusion.The Biochemical journal · 2011Article
- Acid stability of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity.PLoS pathogens · 2011Article
- Cell entry of enveloped viruses.Current opinion in virology · 2011Review
- Driving a wedge between viral lipids blocks infection.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Negative potentials across biological membranes promote fusion by class II and class III viral proteins.Molecular biology of the cell · 2010Article
- Cytoskeleton reorganization in influenza hemagglutinin-initiated syncytium formation.Biochimica et biophysica acta · 2009Article
- Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm.Retrovirology · 2008Review
- Viral and developmental cell fusion mechanisms: conservation and divergence.Developmental cell · 2008Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At the time of fusion, membranes are packed with fusogenic proteins. Do adjacent individual proteins interact with each other in the plane of the membrane? Or does each of these proteins serve as an independent fusion machine? Here we report that the low pH-triggered transition between the initial and final conformations of a prototype fusogenic protein, influenza hemagglutinin (HA), involves a preserved interaction between individual HAs. Although the HAs of subtypes H3 and H2 show notably different degrees of activation, for both, the percentage of low pH-activated HA increased with higher surface density of HA, indicating positive cooperativity. We propose that a concerted activation of HAs, together with the resultant synchronized release of their conformational energy, is an example of a general strategy of coordination in biological design, crucial for the functioning of multiprotein fusion machines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.