ArticleBritish journal of pharmacology2001
Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Evidence of a broad histamine footprint on the human exercise transcriptome.The Journal of physiology · 2016Trial
- Co-existence of Ménétrier's Disease and Collagenous Colitis: A Diagnostic and Therapeutic Challenge.Journal of general internal medicine · 2026Article
- Proton Pump Inhibitors Worsen Colorectal Cancer Outcomes in Patients Treated with Bevacizumab.Cancers · 2024Article
- Review
- Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer.Scientific reports · 2022Article
- Expression of Histidine Decarboxylase and Its Roles in Inflammation.International journal of molecular sciences · 2019Review
- Histamine therapeutic efficacy in metastatic melanoma: Role of histamine H4 receptor agonists and opportunity for combination with radiation.Oncotarget · 2017Article
- Analysis of circulating vascular endothelial growth factor and its soluble receptors in patients with different forms of chronic urticaria.BioMed research international · 2015Article
- Repurposing drugs in oncology (ReDO)-cimetidine as an anti-cancer agent.Ecancermedicalscience · 2014Article
- Therapeutic potential of histamine H₄ receptor agonists in triple-negative human breast cancer experimental model.British journal of pharmacology · 2013Article
- The expression of non-mast histamine in tumor associated microvessels in human colorectal cancers.Pathology oncology research : POR · 2013Article
- Chemical constituents and antihistamine activity of Bixa orellana leaf extract.BMC complementary and alternative medicine · 2013Article
- Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms.Laboratory investigation; a journal of technical methods and pathology · 2012Article
- Mast cells and histamine: do they influence placental vascular network and development in preeclampsia?Mediators of inflammation · 2012Article
- Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Article
- Bone marrow angiogenesis and progression in multiple myeloma.American journal of blood research · 2011Article
- Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants.BMC developmental biology · 2008Article
- The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension.Journal of translational medicine · 2007Review
- Effects of antisecretory agents on angiogenesis during healing of gastric ulcers.Journal of gastroenterology · 2005Article
- Inhibition by acharan sulphate of angiogenesis in experimental inflammation models.British journal of pharmacology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Roles of histamine in the production of vascular endothelial growth factor (VEGF) in the carrageenin-induced granulation tissue in rats were analysed in vitro and in vivo. 2. Incubation of the minced granulation tissue in the presence of histamine (1 and 10 microM) increased the content of VEGF protein in the conditioned medium in a time- and concentration-dependent manner. The levels of VEGF mRNA in the minced granulation tissue were also increased by histamine in a concentration-dependent manner. 3. The increase in the content of VEGF protein in the conditioned medium by histamine (10 microM) was suppressed by the H(2) receptor antagonist cimetidine (IC(50) 0.37 microM), but not by the H(1) receptor antagonist pyrilamine maleate, the H(3) receptor antagonist thioperamide or the cyclo-oxygenase inhibitor indomethacin. 4. The histamine-induced increase in the content of VEGF protein in the conditioned medium was inhibited by the cyclic AMP antagonist Rp-cAMP (IC(50) 6.8 microM), and the protein kinase A inhibitor H-89 (IC(50) 12.5 microM), but not by the protein kinase C inhibitors Ro 31-8425 and calphostin C or the tyrosine kinase inhibitor genistein. 5. Simultaneous injection of cimetidine (400 microg) and indomethacin (100 microg) into the air pouch of rats additively reduced the carrageenin-induced increase in VEGF protein levels and angiogenesis in the granulation tissue as assessed by using carmine dye. 6. These findings indicate that histamine has an activity to induce VEGF production in the granulation tissue via the H(2) receptor-cyclic AMP-protein kinase A pathway and augments angiogenesis in the granulation tissue.
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