ReviewLipids2001
The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis.
Review in Lipids, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- What is the relationship between gestational age and docosahexaenoic acid (DHA) and arachidonic acid (ARA) levels?Prostaglandins, leukotrienes, and essential fatty acids · 2015Trial
- Is choline deficiency an unrecognized factor in necrotizing enterocolitis of preterm infants?Pediatric research · 2024Review
- Neurodevelopmental outcome of infants who develop necrotizing enterocolitis: The gut-brain axis.Seminars in perinatology · 2023Article
- The Role of Dietary Fats in the Development and Prevention of Necrotizing Enterocolitis.Nutrients · 2021Review
- Article
- Breast Milk Lipids and Fatty Acids in Regulating Neonatal Intestinal Development and Protecting against Intestinal Injury.Nutrients · 2020Review
- Docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 MAPK-dependent mechanism.International journal of molecular medicine · 2016Article
- The Role of Immunonutrients in the Prevention of Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants.Nutrients · 2015Review
- Oral administration of surfactant protein-a reduces pathology in an experimental model of necrotizing enterocolitis.Journal of pediatric gastroenterology and nutrition · 2015Article
- Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-κB signaling in the intestine.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- n-3 polyunsaturated fatty acids in the maternal diet modify the postnatal development of nervous regulation of intestinal permeability in piglets.The Journal of physiology · 2011Article
- Effect of pasteurization on selected immune components of donated human breast milk.Journal of perinatology : official journal of the California Perinatal Association · 2011Article
- Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis.Pediatric research · 2010Article
- Necrotizing enterocolitis: a multifactorial disease with no cure.World journal of gastroenterology · 2008Review
- Article
- Immunonutrients and neonates.European journal of pediatrics · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary polyunsaturated fatty acid (PUFA) supplementation has been shown to reduce the incidence of necrotizing enterocolitis (NEC) in a recent randomized, controlled trial. These compounds are known to modulate the inflammatory cascade and to influence intestinal health in a variety of ways. Although the pathophysiology of NEC is not well understood, recent evidence suggests that platelet-activating factor (PAF) is a key endogenous mediator of intestinal necrosis in animals. Using a neonatal rat model of NEC that includes the key risk factors of asphyxia and formula feeding, we investigated the role of dietary PUFA supplementation on the incidence and pathophysiology of NEC. Our findings suggest that PUFA reduce the incidence of NEC by modulating PAF metabolism and endotoxin translocation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.