ReviewLipids2001
Polyunsaturated n-3 fatty acids and the development of atopic disease.
Review in Lipids, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age.Nutrients · 2020Article
- Association of Polymorphism in Fatty Acid Desaturase Gene with the Risk of Type 2 Diabetes in Iranian Population.Advanced biomedical research · 2018Article
- Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts.International journal of epidemiology · 2017Article
- Blood fatty acid composition in relation to allergy in children aged 2-9 years: results from the European IDEFICS study.European journal of clinical nutrition · 2017Article
- Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort.European journal of clinical nutrition · 2013Article
- Fat content, energy value and fatty acid profile of donkey milk during lactation and implications for human nutrition.Lipids in health and disease · 2012Article
- Effects of prenatal and perinatal exposure to fine air pollutants and maternal fish consumption on the occurrence of infantile eczema.International archives of allergy and immunology · 2011Article
- Article
- Factors accounting for the association between anxiety and depression, and eczema: the Hordaland health study (HUSK).BMC dermatology · 2010Article
- Article
- Interactive effects of dietary resistant starch and fish oil on short-chain fatty acid production and agonist-induced contractility in ileum of young rats.Digestive diseases and sciences · 2006Article
- The composition of polyunsaturated fatty acids in erythrocytes of lactating mothers and their infants.Maternal & child nutrition · 2006Article
- Article
- Allergy prevention. Interventions during pregnancy and early infancy.Clinical reviews in allergy & immunology · 2004Review
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between polyunsaturated longchain fatty acids and atopy has been discussed for decades. Higher levels of the essential fatty acids linoleic acid and alpha-linolenic acid and lower levels of their longer metabolites in plasma phospholipids of atopic as compared to nonatopic individuals have been reported by several, but not all, studies. Largely similar findings have been reported in studies of cell membranes from immunological cells from atopics and non-atopics despite differences in methodology, study groups, and definitions of atopy. An imbalance in the metabolism of the n-6 fatty acids, particularly arachidonic acid and dihomo-gamma-linolenic acid, leading to an inappropriate synthesis of prostaglandin (PG) E2 and PGE1 was hypothesized early on but has not been corroborated. The fatty acid composition of human milk is dependent on the time of lactation not only during a breast meal but also the time of the day and the period of lactation. This explains the discrepancies in reported findings regarding the relationship between milk fatty acids and atopic disease in the mother. Prospective studies show disturbances in both the n-6 and n-3 fatty acid composition between milk from atopic and nonatopic mothers. Only the composition of long-chain polyunsaturated n-3 fatty acids was related to atopic development in the children, however. A relationship between lower levels of n-3 fatty acids, particularly eicosapentaenoic acid (20:5 n-3), and early development of atopic disease is hypothesized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.