ArticleApplied and environmental microbiology2001
Role of beta-oxidation enzymes in gamma-decalactone production by the yeast Yarrowia lipolytica.
Article in Applied and environmental microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 121 citations in OpenAlex.
- A synthetic metabolic pathway for the de novo biosynthesis of medium chain length γ- and δ-lactones.Journal of biological engineering · 2025Article
- Valorization of Oil Cakes in Two-Pot Lactone Biosynthesis Process.Foods (Basel, Switzerland) · 2025Article
- EngineeringFrontiers in bioengineering and biotechnology · 2022Article
- Nitrogen as the major factor influencing gene expression inBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Review
- Acyl-CoA oxidase 1 is involved in γ-decalactone release from peach (Prunus persica) fruit.Plant cell reports · 2017Article
- Production of γ-Decalactone by Yeast Strains under Different Conditions.Food technology and biotechnology · 2017Article
- Comparison of Biochemical Properties of the Original and Newly Identified Oleate Hydratases from Stenotrophomonas maltophilia.Applied and environmental microbiology · 2017Article
- Biotechnological production of γ-decalactone, a peach like aroma, by Yarrowia lipolytica.World journal of microbiology & biotechnology · 2016Review
- Non-Conventional Yeasts Whole Cells as Efficient Biocatalysts for the Production of Flavors and Fragrances.Molecules (Basel, Switzerland) · 2015Review
- New biotransformation process for production of the fragrant compound γ-dodecalactone from 10-hydroxystearate by permeabilized Waltomyces lipofer cells.Applied and environmental microbiology · 2013Article
- Biotransformations utilizing β-oxidation cycle reactions in the synthesis of natural compounds and medicines.International journal of molecular sciences · 2012Review
- The 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products.Microbial biotechnology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some microorganisms can transform methyl ricinoleate into gamma-decalactone, a valuable aroma compound, but yields of the bioconversion are low due to (i) incomplete conversion of ricinoleate (C(18)) to the C(10) precursor of gamma-decalactone, (ii) accumulation of other lactones (3-hydroxy-gamma-decalactone and 2- and 3-decen-4-olide), and (iii) gamma-decalactone reconsumption. We evaluated acyl coenzyme A (acyl-CoA) oxidase activity (encoded by the POX1 through POX5 genes) in Yarrowia lipolytica in lactone accumulation and gamma-decalactone reconsumption in POX mutants. Mutants with no acyl-CoA oxidase activity could not reconsume gamma-decalactone, and mutants with a disruption of pox3, which encodes the short-chain acyl-CoA oxidase, reconsumed it more slowly. 3-Hydroxy-gamma-decalactone accumulation during transformation of methyl ricinoleate suggests that, in wild-type strains, beta-oxidation is controlled by 3-hydroxyacyl-CoA dehydrogenase. In mutants with low acyl-CoA oxidase activity, however, the acyl-CoA oxidase controls the beta-oxidation flux. We also identified mutant strains that produced 26 times more gamma-decalactone than the wild-type parents.
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