ArticleImmunology2001
Contribution of conformational stability of hen lysozyme to induction of type 2 T-helper immune responses.
Article in Immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
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- Designs of Antigen Structure and Composition for Improved Protein-Based Vaccine Efficacy.Frontiers in immunology · 2020Review
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- Influence of protein fold stability on immunogenicity and its implications for vaccine design.Expert review of vaccines · 2017Review
- Heat processing of peanut seed enhances the sensitization potential of the major peanut allergen Ara h 6.Molecular nutrition & food research · 2016Article
- Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen.The Journal of allergy and clinical immunology · 2016Article
- Immunogenicity of antibody drug conjugates: bioanalytical methods and monitoring strategy for a novel therapeutic modality.The AAPS journal · 2015Article
- Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis.The Journal of experimental medicine · 2006Article
- Antibody-mediated immunomodulation: a strategy to improve host responses against microbial antigens.Infection and immunity · 2005Review
- Redirecting the humoral immune response against Streptococcus mutans antigen P1 with monoclonal antibodies.Infection and immunity · 2004Article
- Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus.BMC immunology · 2003Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is important to identify characteristics that confer on proteins the potential to induce allergenic sensitization and allergenic disease. Protein allergens carry T-cell epitopes that are capable of inducing a type 2 T helper (Th2) cell response. There is limited information regarding factors that govern the allergenicity of proteins. We previously reported that a decrease in the conformational stability of hen-egg lysozyme (HEL) enhanced its capacity to activate HEL-specific T cells owing to the increased susceptibility to intracellular antigen processing. To determine whether the conformational stability of HEL makes for a critical contribution to allergenic sensitization in vivo, we immunized BALB/c mice with HEL derivatives of different conformational stability, but which retained a similar three-dimensional structure. The magnitude of in vivo T-cell responses, evaluated by ex vivo proliferative responses of lymph node T cells from mice primed with various HEL derivatives, was inversely correlated with conformational stability, as was interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) production by splenic T cells in response to HEL. Immunization of the least stable derivative led to a potent IL-4 response and to immunoglobulin E (IgE) antibody production. We propose that the intrinsic allergenicity of proteins can be determined by the degree of conformational stability.
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