ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2001
Genes, isochores and bands in human chromosomes 21 and 22.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Review
- The formation of chromatin domains involves a primary step based on the 3-D structure of DNA.Scientific reports · 2018Article
- Chromosome Architecture and Genome Organization.PloS one · 2015Article
- Segmenting the Human Genome into Isochores.Evolutionary bioinformatics online · 2015Article
- The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density.Chromosoma · 2008Article
- Replication timing, chromosomal bands, and isochores.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Human chromosomal bands: nested structure, high-definition map and molecular basis.Chromosoma · 2007Article
- A new platform linking chromosomal and sequence information.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
- Gene-rich and gene-poor chromosomal regions have different locations in the interphase nuclei of cold-blooded vertebrates.Chromosoma · 2006Article
- Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recently available DNA sequences from chromosomes 21 and 22 enabled us to define the relationships of different band types with isochores and with gene concentration and to compare these relationships with previous results. We showed that chromosomal bands appear as Giemsa or Reverse bands depending not on their absolute GC level, but on the composition GC level relative to those of adjacent contiguous bands. We also demonstrated that the GC-richest, and gene-richest H3+ bands are characterized by a lower DNA compaction compared with the GC-poorest, gene-poorest L1+ bands. Moreover, our results indicate that the human genome contains about 30,000 genes.
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