ArticleBiophysical journal2001
Deformation-enhanced fluctuations in the red cell skeleton with theoretical relations to elasticity, connectivity, and spectrin unfolding.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 119 citations in OpenAlex.
- Pathophysiological Associations and Measurement Techniques of Red Blood Cell Deformability.Biosensors · 2025Review
- Mechanical adaptivity of red blood cell flickering to extrinsic membrane stiffening by the solid-like biosurfactant β-Aescin.Biophysical journal · 2025Article
- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- Physical mechanisms of red blood cell splenic filtration.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A particle-based computational model to analyse remodelling of the red blood cell cytoskeleton during malaria infections.PLoS computational biology · 2022Article
- Red blood cells under flow show maximal ATP release for specific hematocrit.Biophysical journal · 2021Article
- An Active Biomechanical Model of Cell Adhesion Actuated by Intracellular Tensioning-Taxis.Biophysical journal · 2020Article
- Article
- Axonal cytomechanics in neuronal development.Journal of biosciences · 2020Review
- Critical role of spectrin in hearing development and deafness.Science advances · 2019Article
- Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes?Biophysical journal · 2018Article
- Erythrocyte Aging, Protection via Vesiculation: An Analysis Methodology via Oscillatory Flow.Frontiers in physiology · 2018Article
- Article
- Biomechanical properties of red blood cells in health and disease towards microfluidics.Biomicrofluidics · 2014Review
- Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes.The Journal of biological chemistry · 2012Article
- Cytoskeletal strains in modeled optohydrodynamically stressed healthy and diseased biological cells.Journal of biophysics (Hindawi Publishing Corporation : Online) · 2012Article
- Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells.Scientific reports · 2012Article
- Membrane compartmentalization in Southeast Asian ovalocytosis red blood cells.British journal of haematology · 2011Article
- Analysis of the kinetics of band 3 diffusion in human erythroblasts during assembly of the erythrocyte membrane skeleton.British journal of haematology · 2010Article
- Nanomechanics of multiple units in the erythrocyte membrane skeletal network.Annals of biomedical engineering · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess local elasticity in the red cell's spectrin-actin network, nano-particles were tethered to actin nodes and their constrained thermal motions were tracked. Cells were both immobilized and controllably deformed by aspiration into a micropipette. Since the network is well-appreciated as soft, thermal fluctuations even in an unstressed portion of network were expected to be many tens of nanometers based on simple equipartition ideas. Real-time particle tracking indeed reveals such root-mean-squared motions for 40-nm fluorescent beads either tethered to actin directly within a cell ghost or connected to actin from outside a cell via glycophorin. Moreover, the elastically constrained displacements are significant on the scale of the network's internodal distance of approximately 60-80 nm. Surprisingly, along the aspirated projection-where the network is axially extended by as much as twofold or more-fluctuations in the axial direction are increased by almost twofold relative to motions in the unstressed network. The molecular basis for such strain softening is discussed broadly in terms of force-driven transitions. Specific considerations are given to 1) protein dissociations that reduce network connectivity, and 2) unfolding kinetics of a localized few of the red cell's approximately 10(7) spectrin repeats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.