ArticleBiophysical journal2001
Multi-stage regulation, a key to reliable adaptive biochemical pathways.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Excitation and adaptation in bacteria-a model signal transduction system that controls taxis and spatial pattern formation.International journal of molecular sciences · 2013Article
- Reaction-diffusion systems in intracellular molecular transport and control.Angewandte Chemie (International ed. in English) · 2010Review
- Differential activation of Escherichia coli chemoreceptors by blue-light stimuli.Journal of bacteriology · 2006Article
- Changing cellular location of CheZ predicted by molecular simulations.PLoS computational biology · 2006Article
- Design principles of a bacterial signalling network.Nature · 2005Article
- Single-cell FRET imaging of phosphatase activity in the Escherichia coli chemotaxis system.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Model of bacterial band formation in aerotaxis.Biophysical journal · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A general "multi-stage" regulation model, based on linearly connected regulatory units, is formulated to demonstrate how biochemical pathways may achieve high levels of accuracy. The general mechanism, which is robust to changes in biochemical parameters, such as protein concentration and kinetic rate constants, is incorporated into a mathematical model of the bacterial chemotaxis network and provides a new framework for explaining regulation and adaptiveness in this extensively studied system. Although conventional theories suggest that methylation feedback pathways are responsible for chemotactic regulation, the model, which is deduced from known experimental data, indicates that protein interactions downstream of the bacterial receptor complex, such as CheAs and CheZ, may play a crucial and complementary role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.