ArticleBritish journal of cancer2001
Laminin-1-induced migration of multiple myeloma cells involves the high-affinity 67 kD laminin receptor.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myeloma.Life science alliance · 2023Article
- Regulation of Epithelial-to-Mesenchymal Transition by Alternative Translation Initiation Mechanisms and Its Implications for Cancer Metastasis.International journal of molecular sciences · 2020Review
- Article
- Humoral Immunity vs.Frontiers in immunology · 2019Review
- 67 kDa laminin receptor (67LR) in normal and neoplastic hematopoietic cells: is its targeting a feasible approach?Translational medicine @ UniSa · 2016Article
- A novel biomarker C6orf106 promotes the malignant progression of breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- C6orf106 enhances NSCLC cell invasion by upregulating vimentin, and downregulating E-cadherin and P120ctn.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Augmented expression of urokinase plasminogen activator and extracellular matrix proteins associates with multiple myeloma progression.Clinical & experimental metastasis · 2014Article
- Anti-LRP/LR specific antibody IgG1-iS18 impedes adhesion and invasion of liver cancer cells.PloS one · 2014Article
- scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints.Gene therapy · 2013Article
- PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition.Nucleic acids research · 2012Article
- 37-kDa laminin receptor precursor mediates GnRH-II-induced MMP-2 expression and invasiveness in ovarian cancer cells.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Green tea polyphenol sensing.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2011Review
- Laminin-111: a potential therapeutic agent for Duchenne muscular dystrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Article
- Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone disease.British journal of haematology · 2009Article
- Extravasation and homing mechanisms in multiple myeloma.Clinical & experimental metastasis · 2008Review
- Article
- Article
- Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3.British journal of cancer · 2003Article
- Mechanisms involved in the differential bone marrow homing of CD45 subsets in 5T murine models of myeloma.Clinical & experimental metastasis · 2002Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 67 kD laminin receptor (67LR) binds laminin-1 (LN), major component of the basement membrane, with high affinity. In this study, we demonstrated that human multiple myeloma cell lines (HMCL) and murine 5T2MM cells express 67LR. CD38(bright+) plasma cells in fresh multiple myeloma (MM) bone marrow (BM) samples showed weaker 67LR expression, but expression increased after direct exposure to a BM endothelial cell line (4LHBMEC). LN stimulated the in vitro migration of 3 HMCL (MM5.1, U266 and MMS.1), primary MM cells and the murine 5T2MM cells. 67LR has been shown to mediate the actions of LN through binding to CDPGYIGSR, a 9 amino acid sequence from the B1 chain of LN. MM cell migration was partially blocked by peptide 11, a synthetic nonapeptide derived from this amino sequence and also by a blocking antiserum against 67LR. Co-injection of peptide 11 with 5T2MM cells in a murine in vivo model of MM resulted in a decreased homing of 5T2MM cells to the BM compartment. In conclusion, LN acts as a chemoattractant for MM cells by interaction with 67LR. This interaction might be important during extravasation of circulating MM cells.
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