ArticleBritish journal of cancer2001
Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 148 citations in OpenAlex.
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- The significance of SMARCB1 in the pathogenesis of renal cell carcinoma with rhabdoid features.Translational oncology · 2021Article
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- PBMC gene expression profiles of female Bangladeshi adults chronically exposed to arsenic-contaminated drinking water.Environmental pollution (Barking, Essex : 1987) · 2020Article
- Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Autotaxin-β interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis.Oncotarget · 2018Article
- Role of autotaxin in cancer stem cells.Cancer metastasis reviews · 2018Review
- Key miRNAs and target genes played roles in the development of clear cell renal cell carcinoma.Cancer biomarkers : section A of Disease markers · 2018Article
- Prognostic value of copper transporter 1 expression in patients with clear cell renal cell carcinoma.Oncology letters · 2017Article
- Loss of cadherin related family member 5 (CDHR5) expression in clear cell renal cell carcinoma is a prognostic marker of disease progression.Oncotarget · 2017Article
- PCDH8 inhibits glioma cell proliferation by negatively regulating the AKT/GSK3β/β-catenin signaling pathway.Oncology letters · 2017Article
- XBP1-LOX Axis is critical in ER stress-induced growth of lung adenocarcinoma in 3D culture.American journal of translational research · 2017Article
- Overexpression of autotaxin is associated with human renal cell carcinoma and bladder carcinoma and their progression.Medical oncology (Northwood, London, England) · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal cell carcinoma (RCC) are frequently chemo- and radiation resistant. Thus, there is a need for identifying biological features of these cells that could serve as alternative therapeutic targets. We performed suppression subtractive hybridization (SSH) on patient-matched normal renal and RCC tissue to identify variably regulated genes. 11 genes were strongly up-regulated or selectively expressed in more than one RCC tissue or cell line. Screening of filters containing cancer-related cDNAs confirmed overexpression of 3 of these genes and 3 additional genes were identified. These 14 differentially expressed genes, only 6 of which have previously been associated with RCC, are related to tumour growth/survival (EGFR, cyclin D1, insulin-like growth factor-binding protein-1 and a MLRQ sub-unit homologue of the NADH:ubiquinone oxidoreductase complex), angiogenesis (vascular endothelial growth factor, endothelial PAS domain protein-1, ceruloplasmin, angiopoietin-related protein 2) and cell adhesion/motility (protocadherin 2, cadherin 6, autotaxin, vimentin, lysyl oxidase and semaphorin G). Since some of these genes were overexpressed in 80-90% of RCC tissues, it is important to evaluate their suitability as therapeutic targets.
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