ArticleJournal of the American Society for Mass Spectrometry2001
Hydrogen-deuterium exchange at non-labile sites: a new reaction facet with broad implications for structural and dynamic determinations.
Article in Journal of the American Society for Mass Spectrometry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Targeted Strategy to Analyze Antiepileptic Drugs in Human Serum by LC-MS/MS and LC-Ion Mobility-MS.Analytical chemistry · 2020Article
- Supporting non-target identification by adding hydrogen deuterium exchange MS/MS capabilities to MetFrag.Analytical and bioanalytical chemistry · 2019Article
- Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of DJournal of the American Society for Mass Spectrometry · 2018Article
- The hydrogen-deuterium exchange at α-carbon atom in N,N,N-trialkylglycine residue: ESI-MS studies.Journal of the American Society for Mass Spectrometry · 2012Article
- Gas-Phase Hydrogen/Deuterium Exchange of Dinucleotides and 5'-Monophosphate Dinucleotides in a Quadrupole Ion Trap.International journal of mass spectrometry · 2009Article
- Isomeric differentiation of green tea catechins using gas-phase hydrogen/deuterium exchange reactions.Journal of the American Society for Mass Spectrometry · 2007Article
- Gas-phase hydrogen/deuterium exchange of 5'- and 3'-mononucleotides in a quadrupole ion trap: exploring the role of conformation and system energy.Journal of the American Society for Mass Spectrometry · 2007Article
- Elucidation of the presence and location of t-Boc protecting groups in amines and dipeptides using on-column H/D exchange HPLC/ESI/MS.Journal of the American Society for Mass Spectrometry · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen-deuterium exchange at non-labile sites is reported. The conjugate bases of isophthalic acid (m-C6H4(CO2H)2), 2-oxoglutaric acid (HO2CCOCH2CH2CO2H), and 2-methylisophthalic acid (2-CH3-1,3-C6H4(CO2H)2) undergo scrambling with 1, 2, and 3 carbon-centered hydrogens under a variety of conditions. Likewise, protonated 2-(m-methoxyphenyl)-ethylamine ((m-CH3OC6H4)CH2CH2NH2) undergoes up to 5 H/D exchanges upon gentle activation whereas the conjugate acid of 2-phenylethylamine (C6H5CH2CH2NH2) requires the presence of ammonia-d3 in order to be pushed to undergo up to 8 H/D exchanges. The very act of electrospraying ions can result in extensive movement of deuterium to carbon centers and, in some cases, could not be prevented. These findings offer great promise for future exploitation but also suggest that the interpretation of many H/D exchange experiments using mass spectrometry as the analytical tool could be in error.
Indexed as
Identifiers
11720390What OpenQuestion holds
Registered trials
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