ArticleRNA (New York, N.Y.)2001
Cellular mutants define a common mRNA degradation pathway targeting cytokine AU-rich elements.
Article in RNA (New York, N.Y.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 102 citations in OpenAlex.
- Effect of the p38 Mitogen-Activated Protein Kinase Signaling Cascade on Radiation Biodosimetry.Radiation research · 2022Article
- RNA motifs and combinatorial prediction of interactions, stability and localization of noncoding RNAs.Nature structural & molecular biology · 2018Review
- Inflammation-regulated mRNA stability and the progression of vascular inflammatory diseases.Clinical science (London, England : 1979) · 2017Review
- Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study.Scientific reports · 2017Article
- Effect of the p53-tristetraprolin-stathmin-1 pathway on trophoblasts at maternal-fetal interface.PloS one · 2017Article
- Nonsense mutations in the rhodopsin gene that give rise to mild phenotypes trigger mRNA degradation in human cells by nonsense-mediated decay.Experimental eye research · 2016Article
- Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.RNA (New York, N.Y.) · 2016Article
- Can we observe changes in mRNA "state"? Overview of methods to study mRNA interactions with regulatory proteins relevant in cancer related processes.The Analyst · 2016Review
- Tristetraprolin regulation of interleukin-22 production.Scientific reports · 2015Article
- Translating the Untranslated Region.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- Activation of silenced cytokine gene promoters by the synergistic effect of TBP-TALE and VP64-TALE activators.PloS one · 2014Article
- An optimized streptavidin-binding RNA aptamer for purification of ribonucleoprotein complexes identifies novel ARE-binding proteins.Nucleic acids research · 2014Article
- Post-transcriptional regulatory networks in immunity.Immunological reviews · 2013Review
- Article
- MAPK usage in periodontal disease progression.Journal of signal transduction · 2012Article
- The role of tristetraprolin in cancer and inflammation.Frontiers in bioscience (Landmark edition) · 2012Review
- Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation.Molecular systems biology · 2011Article
- Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells.Molecular biology of the cell · 2011Article
- Article
- Early recruitment of AU-rich element-containing mRNAs determines their cytosolic fate during iron deficiency.Molecular and cellular biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To functionally classify AU-rich elements (AREs) from six different cytokine mRNAs, we made use of two previously described HT1080-derived cellular mutants (slowA, slowC) that lack a function required for the rapid degradation of interleukin-3 (IL-3) mRNA. Here we show that the defect is specific for ARE-containing mRNAs, whereas nonsense-mediated decay is intact. Degradation of beta-globin reporter transcripts mediated by the AREs of IL-3, GM-CSF, and TNFalpha, as well as by the structurally different and less potent AREs of IL-2 and IL-6, is impaired in both mutants. All these reporter transcripts are also sensitive to decay induced by ectopic expression of the RNA-binding protein tristetraprolin in the slowC background. Thus, we concluded that the mutants slowA and slowC define a common mRNA degradation pathway that targets cytokine AREs. In NIH3T3 cells, this decay pathway becomes incapacitated by upstream signaling from p38 MAP- or PI3-kinases, which independently stabilize cytokine ARE-containing transcripts. In contrast, c-fos ARE-directed mRNA degradation proceeds through a different pathway not affected by these kinases.
Indexed as
Identifiers
11720287PMC1370200W2130276974What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.