Evidence map›Paper›PMID 11720281›Full record

ReviewRNA (New York, N.Y.)2001

The rest is silence.

E Bernstein, A M Denli, G J Hannon

Abstract readReview
In one paragraph

Review in RNA (New York, N.Y.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  5. Connecting the dots of RNA-directed DNA methylation in Arabidopsis thaliana.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Role of F-Box Proteins during Viral Infection.International journal of molecular sciences · 2013
    Article
  12. Article
  13. Article
  14. Article
  15. A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA.Molecular therapy : the journal of the American Society of Gene Therapy · 2011
    Article
  16. Article
  17. Article
  18. Article
  19. Effective shutdown in the expression of celiac disease-related wheat gliadin T-cell epitopes by RNA interference.Proceedings of the National Academy of Sciences of the United States of America · 2010
    Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

E BernsteinCold Spring Harbor Laboratory, Watson School of Biological Sciences, New York 11724, USA.
A M Denli
G J Hannon

Funding

MECHANISMS OF DSRNA-INDUCED GENE SILENCINGR01GM062534 · NIGMS · COLD SPRING HARBOR LABORATORY · PI HANNON, GREGORY J · 2000 to 2012
$4.3M
NIGMS NIH HHS R01-GM62534
6 · The paper itself

Abstract

Over the past several years, RNAi and its related phenomena have emerged not only as a powerful experimental tool but also as a new mode of gene regulation. Through a combination of genetic and biochemical approaches we have learned much about the mechanisms underlying dsRNA responses. However, many of the most intriguing aspects of dsRNA-induced gene silencing have yet to be illuminated. What has become abundantly clear is that the complex and highly conserved biology underlying RNA interference is critical both for genome maintenance and for the development of complex organisms. However, it seems probable that we have only begun to reveal the diversity of biological roles played by RNAi-related processes.

Indexed as

Gene SilencingRNA Processing, Post-TranscriptionalAnimalsRNA, Double-StrandedRNA, Small InterferingRNA, UntranslatedTransgenesRNA, Double-StrandedRNA, Small InterferingRNA, Untranslated

Identifiers

PMID11720281
PMCPMC1370194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.