ArticleBMJ (Clinical research ed.)2001
Differences between perspectives of physicians and patients on anticoagulation in patients with atrial fibrillation: observational study.
Article in BMJ (Clinical research ed.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07705282 (Standalone Thoracoscopic Left Atrial Appendage Closure Versus Medical Therapy in Atrial Fibrillation), which is not on this map. Cited by 125 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Standalone Thoracoscopic Left Atrial Appendage Closure Versus Medical Therapy in Atrial Fibrillation
Who cites it
125 citing papers in PubMed, 10 syntheses or guidelines pooled it, 415 citations in OpenAlex.
- Risk of Intracranial Hemorrhage Associated With Direct Oral Anticoagulation vs Antiplatelet Therapy: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Curative efficacy of surgical procedures for older patients with femoral neck fracture: a network meta-analysis and systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Guideline Adherence As An Indicator of the Extent of Antithrombotic Overuse and Underuse: A Systematic Review.Global heart · 2022Pooled it
- Women's Values and Preferences Regarding Osteoporosis Treatments: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2019Pooled it
- Patient Preferences for Oral Anticoagulation Therapy in Atrial Fibrillation: A Systematic Literature Review.The patient · 2017Pooled it
- Self-monitoring and self-management of oral anticoagulation.The Cochrane database of systematic reviews · 2016Pooled it
- European Primary Care Cardiovascular Society (EPCCS) consensus guidance on stroke prevention in atrial fibrillation (SPAF) in primary care.European journal of preventive cardiology · 2016Guideline
- Pooled it
- Pooled it
- A systematic review of postcoital bleeding and risk of cervical cancer.The British journal of general practice : the journal of the Royal College of General Practitioners · 2006Pooled it
- Cost-effectiveness of apixaban vs. aspirin for the reduction of thrombo-embolism in high-risk patients with device-detected atrial fibrillation: insights from the ARTESiA trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Trial
- Patients and Their Physician's Perspectives About Oral Anticoagulation in Patients With Atrial Fibrillation Not Receiving an Anticoagulant.JAMA network open · 2023Trial
- Randomized Clinical Trial to Evaluate an Atrial Fibrillation Stroke Prevention Shared Decision-Making Pathway.Journal of the American Heart Association · 2023Trial
- Effect of Mailing Educational Material to Patients With Atrial Fibrillation and Their Clinicians on Use of Oral Anticoagulants: A Randomized Clinical Trial.JAMA network open · 2022Trial
- Trial
- Improving stroke prevention therapy for patients with atrial fibrillation in primary care: protocol for a pragmatic, cluster-randomized trial.Implementation science : IS · 2016Trial
- The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.European heart journal · 2015Trial
- Patient perspective on the management of atrial fibrillation in five European countries.BMC cardiovascular disorders · 2013Trial
- Evaluating patient values and preferences for thromboprophylaxis decision making during pregnancy: a study protocol.BMC pregnancy and childbirth · 2012Trial
- What are the barriers to warfarin use in atrial fibrillation?: Development of a questionnaire.Journal of thrombosis and thrombolysis · 2006Trial
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine and compare physicians' and patients' thresholds for how much reduction in risk of stroke is necessary and how much risk of excess bleeding is acceptable with antithrombotic treatment in people with atrial fibrillation.
designProspective observational study.
settingTertiary and peripheral referral centres in Nova Scotia, Canada.
participants63 physicians who were treating patients with atrial fibrillation and 61 patients at high risk for atrial fibrillation.
main outcome measuresParticipants underwent a face to face interview with a probability trade-off tool. Thresholds were determined for the minimum reduction in risk of stroke necessary and the maximum increase in risk of excess bleeding acceptable for treatment with aspirin and warfarin in people with atrial fibrillation.
resultsThe minimum number of strokes that needed to be prevented in 100 patients over two years for warfarin to be justified was significantly lower for patients than for physicians (1.8 (SD 1.9) v 2.5 (1.6), P=0.009), whereas for aspirin there was no difference between patients and physicians (1.3 (1.3) v 1.6 (1.5), P=0.29). The maximum number of excess bleeds acceptable in 100 patients over two years for use of warfarin and aspirin was significantly higher for patients than for physicians (warfarin 17.4 (7.1) v 10.3 (6.1); aspirin 14.7 (8.5) v 6.7 (6.2); P<0.001 for both comparisons).
conclusionsPatients at high risk for atrial fibrillation placed more value on the avoidance of stroke and less value on the avoidance of bleeding than did physicians who treat patients with atrial fibrillation. The views of the individual patient should be considered when decisions are being made about antithrombotic treatment for people with atrial fibrillation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.