ArticleJournal of neuro-oncology2001
Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas.
Article in Journal of neuro-oncology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
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- Aptamer-Based In Vivo Therapeutic Targeting of Glioblastoma.Molecules (Basel, Switzerland) · 2020Review
- Promoted Growth of Brain Tumor by the Transplantation of Neural Stem/Progenitor Cells Facilitated by CXCL12.Translational oncology · 2014Article
- Vasculogenesis: a crucial player in the resistance of solid tumours to radiotherapy.The British journal of radiology · 2014Review
- Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats.Neuro-oncology · 2014Article
- In vivo characterization of several rodent glioma models by 1H MRS.NMR in biomedicine · 2012Article
- Quantitative monitoring of mouse lung tumors by magnetic resonance imaging.Nature protocols · 2012Article
- Angiogenic signalling pathways altered in gliomas: selection mechanisms for more aggressive neoplastic subpopulations with invasive phenotype.Journal of signal transduction · 2012Article
- NG2-expressing glial precursor cells are a new potential oligodendroglioma cell initiating population in N-ethyl-N-nitrosourea-induced gliomagenesis.Carcinogenesis · 2010Article
- Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography.Journal of magnetic resonance imaging : JMRI · 2010Article
- Molecular magnetic resonance imaging approaches used to aid in the understanding of angiogenesis in vivo: implications for tissue engineering.Tissue engineering. Part A · 2010Article
- VEGF immunopositivity related to malignancy degree, proliferative activity and angiogenesis in ENU-induced gliomas.Journal of molecular neuroscience : MN · 2007Article
- Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.The American journal of pathology · 2006Article
- MRI detection of early bone metastases in b16 mouse melanoma models.Clinical & experimental metastasis · 2005Article
- In vivo detection of c-Met expression in a rat C6 glioma model.Journal of cellular and molecular medicineArticle
- MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials.Neoplasia (New York, N.Y.)Article
- Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model--an MRI study.Neoplasia (New York, N.Y.)Article
Corrections and comments
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7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human low-grade gliomas represent a population of brain tumors that remain a therapeutic challenge. Preclinical evaluation of agents, to test their preventive or therapeutic efficacy in these tumors, requires the use of animal models. Spontaneous gliomas develop in models of chemically induced carcinogenesis, such as in the transplacental N-ethyl-N-nitrosourea (ENU) rat model. However, without the ability to detect initial tumor formation, multiplicity or to measure growth rates, it is difficult to test compounds for their interventional or preventional capabilities. In this study Fisher-334 rats, treated transplacentally with ENU, underwent magnetic resonance imaging (MRI) examination in order to evaluate this approach for detection of tumor formation and growth. ENU-induced intracranial cerebral tumors were first observable in T2-weighted images beginning at 4 months of age and grew with a mean doubling time of 0.487 +/- 0.112 months. These tumors were found histologically to be predominately mixed gliomas. Two therapeutic interventions were evaluated using MRI, vitamin A (all-trans retinol palmitate, RP), as a chemopreventative agent and the anti-angiogenic drug SU-5416. RP was found to significantly delay the time to first tumor observation by one month (P = 0.05). No differences in rates of tumor formation or growth rates were observed between control and RP-treated groups. MRI studies of rats treated with SU-5416 resulted in reduction in tumor growth rates compared to matched controls. These results show that MRI can be used to provide novel information relating to the therapeutic efficacy of agents against the ENU-induced tumor model.
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