ArticleProceedings of the National Academy of Sciences of the United States of America2001
The DELLA motif is essential for gibberellin-induced degradation of RGA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers.
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Who cites it
197 citing papers in PubMed, 478 citations in OpenAlex.
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
- Glycine max DREB1D transcription factor regulates plant height by reducing gibberellin levels and response.Planta · 2026Article
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.bioRxiv : the preprint server for biology · 2026Article
- Dynamic changes of endogenous hormones and transcriptome analysis reveal the regulatory mechanism of gibberellin-promoted male cone formation in Platycladus orientalis.BMC plant biology · 2026Article
- Membrane-associated DELLA degradation modulates growth under carbon/nitrogen imbalance.The Plant cell · 2026Article
- Integrative molecular mechanisms of lodging resistance in rice (Frontiers in plant science · 2026Review
- Genome-wide analysis of theFrontiers in plant science · 2026Article
- ROS-mediated interplay between brassinosteroids and gibberellic acids antagonistically modulates asymmetric periclinal cell division leading to middle cortex formation inPlant signaling & behavior · 2025Article
- A mutation of GRAS SCL14 gene confers moderate sensitivity to the herbicide bentazon in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Multiomics analysis of gibberellin involved in far-red light-regulated internode elongation in cucumber seedlings.Plant cell reports · 2025Article
- Apple DELLA Is Degraded Under Warm Temperature Conditions inPlant direct · 2025Article
- Growth arrest is a DNA damage protection strategy in Arabidopsis.Nature communications · 2025Article
- Transposable elements drive the subgenomic divergence of homoeologous genes to shape wheat domestication and improvement.Plant communications · 2025Article
- Identification of DELLA and GID1 genes in Catharanthus roseus and their potential role in regulating vindoline biosynthesis.Plant molecular biology · 2025Article
- Identification of F-box proteins in ABA- and GA-regulated seed germination: interaction of GASA1 signalling peptide and ABA-induced ubiquitination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Green Revolution DELLA Proteins: Functional Analysis and Regulatory Mechanisms.Annual review of plant biology · 2025Review
- Gibberellic Acid (GAChemistry & biodiversity · 2025Review
- A quantitative gibberellin signaling biosensor reveals a role for gibberellins in internode specification at the shoot apical meristem.Nature communications · 2024Article
- Highlights in gibberellin research: A tale of the dwarf and the slender.Plant physiology · 2024Review
137 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RGA and GAI are homologous genes that encode putative transcriptional regulators that repress gibberellin (GA) signaling in Arabidopsis. Previously we showed that the green fluorescent protein (GFP)-RGA fusion protein is localized to the nucleus in transgenic Arabidopsis, and expression of this fusion protein rescues the rga null mutation. The GA signal seems to derepress the GA response pathway by degrading the repressor protein RGA. The GA-insensitive, semidominant, semidwarf gai-1 mutant encodes a mutant protein with a 17-amino acid deletion within the DELLA domain of GAI. It was hypothesized that this mutation turns the gai protein into a constitutive repressor of GA signaling. Because the sequences missing in gai-1 are identical between GAI and RGA, we tested whether an identical mutation (rga-Delta 17) in the RGA gene would confer a phenotype similar to gai-1. We demonstrated that expression of rga-Delta 17 or GFP-(rga-Delta 17) under the control of the RGA promoter caused a GA-unresponsive severe dwarf phenotype in transgenic Arabidopsis. Analysis of the mRNA levels of a GA biosynthetic gene, GA4, showed that the feedback control of GA biosynthesis in these transgenic plants was less responsive to GA than that in wild type. Immunoblot and confocal microscopy analyses indicated that rga-Delta17 and GFP-(rga-Delta 17) proteins were resistant to degradation after GA application. Our results illustrate that the DELLA domain in RGA plays a regulatory role in GA-induced degradation of RGA. Deletion of this region stabilizes the rga-Delta 17 mutant protein, and regardless of the endogenous GA status rga-Delta 17 becomes a constitutively active repressor of GA signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.