ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Article
- Clinical and Pathologic Features of Congenital Myasthenic Syndromes Caused by 35 Genes-A Comprehensive Review.International journal of molecular sciences · 2023Review
- Presynaptic Congenital Myasthenic Syndromes: Understanding Clinical Phenotypes through In vivo Models.Journal of neuromuscular diseases · 2023Review
- rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.PLoS genetics · 2021Article
- A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release.The Journal of cell biology · 2021Article
- Presynaptic congenital myasthenic syndrome with altered synaptic vesicle homeostasis linked to compound heterozygous sequence variants in RPH3A.Molecular genetics & genomic medicine · 2018Article
- Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.Traffic (Copenhagen, Denmark) · 2014Article
- A gain-of-function mutation in adenylate cyclase confers isoflurane resistance in Caenorhabditis elegans.Anesthesiology · 2011Article
- HID-1, a new component of the peptidergic signaling pathway.Genetics · 2011Article
- Article
- Searching for molecular players differentially involved in neurotransmitter and neuropeptide release.Neurochemical research · 2008Review
- Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse.Genes, brain, and behavior · 2007Article
- Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans.PLoS biology · 2006Article
- Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion.The EMBO journal · 2006Article
- Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans.Molecular biology of the cell · 2006Article
- The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans.Genes & development · 2005Article
- Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector rabphilin-3a.The American journal of pathology · 2003Article
- Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a.Molecular and cellular biology · 2002Article
- A post-docking role for active zone protein Rim.Nature neuroscience · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rabphilin, a putative rab effector, interacts specifically with the GTP-bound form of the synaptic vesicle-associated protein rab3a. In this study, we define in vivo functions for rabphilin through the characterization of mutants that disrupt the Caenorhabditis elegans rabphilin homolog. The mutants do not display the general synaptic defects associated with rab3 lesions, as assayed at the pharmacological, physiological, and ultrastructural level. However, rabphilin mutants exhibit severe lethargy in the absence of mechanical stimulation. Furthermore, rabphilin mutations display strong synergistic interactions with hypomorphic lesions in the syntaxin, synaptosomal-associated protein of 25 kDa, and synaptobrevin soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) genes; double mutants were nonresponsive to mechanical stimulation. These synergistic interactions were independent of rab3 function and were not observed in rab3-SNARE double mutants. Our data reveal rab3-independent functions for rabphilin in the potentiation of SNARE function.
Indexed as
Identifiers
11717359PMC6763921What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.