ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
P2X2 receptor mediates stimulation of parasensory cation absorption by cochlear outer sulcus cells and vestibular transitional cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 89 citations in OpenAlex.
- Single-dose genome editing therapy rescues auditory and vestibular functions in adult mice with DFNA41 deafness.The Journal of clinical investigation · 2025Article
- Differential Effects of Hearing Loss Mutations in Homomeric P2X2 and Heteromeric P2X2/3 Receptors.Cells · 2025Article
- Purinergic signaling in the peripheral vestibular system.Purinergic signalling · 2022Review
- Progress in protecting vestibular hair cells.Archives of toxicology · 2021Review
- P2X2 Dominant Deafness Mutations Have No Negative Effect on Wild-Type Isoform: Implications for Functional Rescue and in Deafness Mechanism.Frontiers in molecular neuroscience · 2017Article
- QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Expression and function of pannexins in the inner ear and hearing.BMC cell biology · 2016Review
- Regulation of the perilymphatic-endolymphatic water shunt in the cochlea by membrane translocation of aquaporin-5.Pflugers Archiv : European journal of physiology · 2015Article
- Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells.Purinergic signalling · 2015Article
- Mechanisms of otoconia and otolith development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Water permeability of the mammalian cochlea: functional features of an aquaporin-facilitated water shunt at the perilymph-endolymph barrier.Pflugers Archiv : European journal of physiology · 2014Article
- Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs.Hearing research · 2013Article
- Preclinical and clinical studies of unrelieved aural fullness following intratympanic gentamicin injection in patients with intractable Ménière's disease.Audiology & neuro-otology · 2013Article
- Expression and localization of ryanodine receptors in the frog semicircular canal.Journal of biomedicine & biotechnology · 2012Article
- The cochlear CRF signaling systems and their mechanisms of action in modulating cochlear sensitivity and protection against trauma.Molecular neurobiology · 2011Review
- Critical roles of transitional cells and Na/K-ATPase in the formation of vestibular endolymph.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Regulation of sodium transport in the inner ear.Hearing research · 2011Review
- Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter.American journal of physiology. Heart and circulatory physiology · 2011Article
- The role of pendrin in the development of the murine inner ear.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2011Review
- Differential expression of P2Y receptors in the rat cochlea during development.Purinergic signalling · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cochlear outer sulcus cells (OSC) and vestibular transitional cells (VTC) are part of the parasensory epithelium in the inner ear and are located in homologous positions between the sensory hair cells and the cation secretory epithelial cells in the cochlea and the vestibular labyrinth. OSC are known to sustain a reabsorptive transepithelial current and to contain an immunoreactivity for P2X(2) purinergic receptors. This study addresses whether OSC and VTC share functional similarities and extends this hypothesis to the question of whether both cell types contain functional P2X(2) receptors. The current density (I(sc)) was recorded with the vibrating probe technique and was found to be similar in VTC and OSC. Both gadolinium and flufenamic acid reduced I(sc) in VTC, as reported previously for OSC. I(sc) was stimulated by extracellular ATP but not by selective agonists of P2Y receptors. Purinergic receptor agonists increased I(sc) with a potency order of ATP > 2'- and 3'-O-(4-benzoyl-benzoyl)adenosine 5'-triphosphate alpha,beta-methyleneadenosine 5'-triphosphate in both OSC and VTC. In the presence of suramin (100 micrometer) or gadolinium (100 micrometer), the responses of ATP were inhibited significantly in both OSC and VTC. This pharmacological profile is consistent with that of the P2X(2) receptor. These results demonstrate that VTC participate in vestibular parasensory cation absorption and that both OSC and VTC regulate their parasensory cation flux via P2X(2) receptors, which would regulate the endolymphatic concentration of the current-carrying ion species in auditory and vestibular transduction.
Indexed as
Identifiers
11717350PMC6763907W1863695291What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.