ReviewJournal of neuro-oncology2001
Biological mechanisms of glioma invasion and potential therapeutic targets.
Review in Journal of neuro-oncology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 101 citations in OpenAlex.
- Uptake patterns of Adult-type Non-Enhanced diffuse gliomas on [Neuroradiology · 2025Article
- Article
- Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas.Cancers · 2024Article
- AssociatingAJNR. American journal of neuroradiology · 2023Article
- Glioblastoma: Current Status, Emerging Targets, and Recent Advances.Journal of medicinal chemistry · 2022Review
- Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives.Cancers · 2022Review
- Enhancement of Therapies for Glioblastoma (GBM) Using Nanoparticle-based Delivery Systems.AAPS PharmSciTech · 2021Review
- Article
- Feasibility of intratumoral 165Holmium siloxane delivery to induced U87 glioblastoma in a large animal model, the Yucatan minipig.PloS one · 2020Article
- Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.BMC cancer · 2019Article
- The Volume-Regulated Anion Channel in Glioblastoma.Cancers · 2019Review
- Extracellular matrix differences in glioblastoma patients with different prognoses.Oncology letters · 2019Article
- Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI.NeuroImage. Clinical · 2018Article
- Tumor Grade versus Expression of Invasion-Related Molecules in Astrocytoma.Pathology oncology research : POR · 2018Article
- The Combined Influence of Hydrogel Stiffness and Matrix-Bound Hyaluronic Acid Content on Glioblastoma Invasion.Macromolecular bioscience · 2017Article
- Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway.Journal of Korean Neurosurgical Society · 2016Article
- Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion.Toxins · 2015Review
- Quantitative proteomic analysis reveals effects of epidermal growth factor receptor (EGFR) on invasion-promoting proteins secreted by glioblastoma cells.Molecular & cellular proteomics : MCP · 2014Article
- Identification of key signaling molecules involved in the activation of the swelling-activated chloride current in human glioblastoma cells.The Journal of membrane biology · 2014Article
- Glioblastoma multiforme - an overview.Contemporary oncology (Poznan, Poland) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current understanding of glioma biology reveals targets for anti-invasive therapy which include manipulations of extracellular matrix and receptors, growth factors and cytokines, proteases, cytoskeletal components, oncogenes and tumor suppressor genes. A better understanding of the complex regulation and the signalling molecules involved in glioma invasion is still needed in order to design new and effective treatment modalities towards invasive tumor cells. Representative and valid in vitro experimental systems and animal models of gliomas are necessary for the characterization of the invasive phenotype and further development of anti-invasive therapy. In the future, it will probably be important to move from comparative genomic modelling through protein characterization based on advanced proteomic techniques to analyse tissue samples, where the aim for gliomas should be to compare invaded and non-invaded tissue. This will hopefully render promising new therapeutic targets for gliomas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.