ArticleThe Journal of cell biology2001
NAPO as a novel marker for apoptosis.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The meaning of death: evolution and ecology of apoptosis in protozoan parasites.PLoS pathogens · 2011Review
- Investigating the evolution of apoptosis in malaria parasites: the importance of ecology.Parasites & vectors · 2010Article
- Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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4 authors.
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Abstract
Apoptosis or programmed cell death plays a pivotal role in embryonic development and maintenance of homeostasis. It is also involved in the etiology of pathophysiological conditions such as cancer, neurodegenerative, autoimmune, infectious, and heart diseases. Consequently, the study of apoptosis is now at center of both basic and clinical research applications. Therefore, sensitive and simple apoptosis detection techniques are required. Here we describe a monoclonal antibody-defined novel antigen, namely NAPO (negative in apoptosis), which is specifically lost during apoptosis. The anti-NAPO antibody recognizes two nuclear polypeptides of 60 and 70 kD. The antigen is maintained in quiescent and senescent cells, as well as in different phases of the cell cycle, including mitosis. Thus, immunodetection of NAPO antigen provides a specific, sensitive, and easy method for differential identification of apoptotic and nonapoptotic cells.
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