ArticleArthritis research2001
Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration.
Article in Arthritis research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis.Irish journal of medical science · 2014Pooled it
- Emerging role of leptin in rheumatoid arthritis.Clinical and experimental immunology · 2014Pooled it
- Chronic Leptin Deficiency Improves Tolerance of Physiological Damage and Host-Pathogen Cooperation during Yersinia pseudotuberculosis Infection.Infection and immunity · 2022Article
- Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?International journal of molecular sciences · 2022Review
- Emergence of Leptin in Infection and Immunity: Scope and Challenges in Vaccines Formulation.Frontiers in cellular and infection microbiology · 2018Review
- Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis.Mediators of inflammation · 2016Article
- Cytokine responses to Staphylococcus aureus bloodstream infection differ between patient cohorts that have different clinical courses of infection.BMC infectious diseases · 2014Article
- Adipokines as potential biomarkers in rheumatoid arthritis.Mediators of inflammation · 2014Article
- The role of adipokines in connective tissue diseases.European journal of nutrition · 2012Review
- Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats.Autoimmunity · 2011Article
- Comparison of the effects of genistein and daidzein with dexamethasone and soy protein on rheumatoid arthritis in rats.BioImpacts : BI · 2011Article
- The role of leptin in innate and adaptive immune responses.Arthritis research & therapy · 2006Review
- Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice.Arthritis research & therapy · 2004Article
- A role for leptin in rheumatic diseases?Annals of the rheumatic diseases · 2003Article
- Leptin consumption in the inflamed joints of patients with rheumatoid arthritis.Annals of the rheumatic diseases · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weight loss is typically found during severe infections, e.g. septic arthritis. The aim of our study was to evaluate the role of leptin, regulator of food intake and energy expenditure, for the development of Staphylococcus aureus-triggered arthritis. Leptin production was found to be decreased during murine S. aureus-induced arthritis. Treatment with recombinant leptin neither restored the basal leptin levels nor affected the weight loss during the disease, but it significantly decreased the severity of septic arthritis. Exogenous leptin did not affect the staphylococcal load as measured in blood, joints and kidneys. Preceding the effects on joint manifestations, serum levels of interleukin-6 decreased in leptin-treated mice. In conclusion, the treatment with recombinant leptin reduced both the severity of joint manifestations in S.aureus-induced arthritis and the inflammatory response, as measured by serum IL-6 levels, without affecting the survival of bacteria in vivo.
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Registered trials
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