ArticleMolecular and cellular biology2001
TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 74 citations in OpenAlex.
- Pontin Acts as a Potential Biomarker for Poor Clinical Outcome and Promotes Tumor Invasion in Hilar Cholangiocarcinoma.BioMed research international · 2018Trial
- Pharmacogenomic of LH and its receptor: are we ready for clinical practice?Reproductive biology and endocrinology : RB&E · 2025Review
- Differential roles of putative arginine fingers of AAAbioRxiv : the preprint server for biology · 2024Article
- RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in MacrophagesFrontiers in immunology · 2021Article
- Sorafenib as an Inhibitor of RUVBL2.Biomolecules · 2020Article
- Review
- Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma.Cancer cell international · 2019Article
- Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine.Neurochemical research · 2016Article
- Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue.Journal of radiation research · 2015Article
- Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases.Nucleic acids research · 2014Article
- Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Connecting chromatin modifying factors to DNA damage response.International journal of molecular sciences · 2013Article
- Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression.Communicative & integrative biology · 2012Article
- ATF2 - at the crossroad of nuclear and cytosolic functions.Journal of cell science · 2012Article
- Relating protein adduction to gene expression changes: a systems approach.Molecular bioSystems · 2011Article
- AtfA bZIP-type transcription factor regulates oxidative and osmotic stress responses in Aspergillus nidulans.Molecular genetics and genomics : MGG · 2010Article
- Cooperative action of TIP48 and TIP49 in H2A.Z exchange catalyzed by acetylation of nucleosomal H2A.Nucleic acids research · 2009Article
- RuvB-like protein 2 is a suppressor of influenza A virus polymerases.Journal of virology · 2009Article
- Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells.Cancer research · 2009Article
- Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1-RuvBL2 complex.Acta crystallographica. Section F, Structural biology and crystallization communications · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Activating transcription factor 2 (ATF2/CRE-BP1) is implicated in transcriptional control of stress-responsive genes. A yeast two-hybrid screen identified TBP-interacting protein 49b (TIP49b), a component of the INO80 chromatin-remodeling complex, as a novel ATF2-interacting protein. TIP49b's association with ATF2 is phosphorylation dependent and requires amino acids 150 to 248 of ATF2 (ATF2(150-248)), which are implicated in intramolecular inhibition of ATF2 transcriptional activities. Forced expression of TIP49b efficiently attenuated ATF2 transcriptional activities under normal growth conditions as well as after UV treatment, ionizing irradiation, or activation of p38 kinase, all of which induced ATF2 phosphorylation and increased TIP49b-ATF2 association. Constitutive expression of ATF2(150-248) peptide outcompeted TIP49b interaction with ATF2 and alleviated the suppression of ATF2 transcriptional activities. Expression of ATF2(150-248) in fibroblasts or melanoma but not in ATF2-null cells caused a profound G(2)M arrest and increased degree of apoptosis following irradiation. The interaction between ATF2 and TIP49b constitutes a novel mechanism that serves to limit ATF2 transcriptional activities and highlights the central role of ATF2 in the control of the cell cycle and apoptosis in response to stress and DNA damage.
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