ReviewEnvironmental health perspectives2001
Increasing the sensitivity of the rodent uterotrophic assay to estrogens, with particular reference to bisphenol A.
Review in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Perinatal Exposure of Bisphenol A Differently Affects Dendritic Spines of Male and Female Grown-Up Adult Hippocampal Neurons.Frontiers in neuroscience · 2021Article
- Estrogen-induced memory enhancements are blocked by acute bisphenol A in adult female rats: role of dendritic spines.Endocrinology · 2012Article
- Bisphenol A interferes with synaptic remodeling.Frontiers in neuroendocrinology · 2010Review
- In vivo profiling of estrogen receptor/specificity protein-dependent transactivation.Endocrinology · 2008Article
- Bisphenol A prevents the synaptogenic response to testosterone in the brain of adult male rats.Endocrinology · 2008Article
- Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network "Phytohealth" (QLKI-2002-2453).Genes & nutrition · 2006Article
- The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesis.Environmental health perspectives · 2005Article
- Increases in mouse uterine heat shock protein levels are a sensitive and specific response to uterotrophic agents.Environmental health perspectives · 2002Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gravimetric uterotrophic assay is currently the most well-established, short-term rodent estrogenicity assay. Increasing attention is being paid to the extent to which use of morphometric or molecular changes in the uterus could act as surrogates for the gravimetric end point of the assay, thereby perhaps increasing the sensitivity of the assay. In this paper I discuss the available data, paying particular attention to studies on bisphenol A (BPA) because it offers the largest database for consideration. I conclude that the case has yet to be made for augmenting the gravimetric end point of the uterotrophic assay. To resolve this important question, it will be necessary to conduct detailed dose-response studies where the no-observed-effect level (NOEL) for the proposed surrogate end points are compared with the NOEL for the gravimetric end point. Currently, few such studies exist, and among those that do no clear message emerges. The general trend to increasing use of molecular assays in toxicology (multigene microarrays and real-time polymerase chain reaction) emphasizes the need for clear criteria for comparing the performance of individual markers of toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.