ArticleJournal of virology2001
Dynamics of persistent TT virus infection, as determined in patients treated with alpha interferon for concomitant hepatitis C virus infection.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Torque teno virus load as marker of rejection and infection in solid organ transplantation - A systematic review and meta-analysis.Reviews in medical virology · 2023Pooled it
- Pre-transplant plasma Torque Teno virus load and increase dynamics after lung transplantation.PloS one · 2015Trial
- Response of TT virus to IFN plus ribavirin treatment in patients with chronic hepatitis C.World journal of gastroenterology · 2004Trial
- A novel Torque teno virus qPCR assay reveals longitudinal viral load variability among non-immunosuppressed subjects.EMBO molecular medicine · 2026Article
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Circulation of Herpesvirus and Alphatorquevirus DNA in each trimester in asymptomatic women pregnant with twins.PloS one · 2025Article
- Anelloviruses versus human immunity: how do we control these viruses?FEMS microbiology reviews · 2024Review
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- Torque teno viruses exhaust and imprint the human immune system via the HLA-E/NKG2A axis.Frontiers in immunology · 2024Article
- Expansion ofViruses · 2023Article
- Evolution of anelloviruses from a circovirus-like ancestor through gradual augmentation of the jelly-roll capsid protein.Virus evolution · 2023Article
- Longitudinal anellome dynamics in the upper respiratory tract of children with acute respiratory tract infections.Virus evolution · 2023Article
- Detailed characterization of Redondovirus in saliva of SARS-CoV-2-infected individuals in Sao Paulo, Brazil.PloS one · 2023Article
- Characterization of Torquetenovirus in amniotic fluid at the time ofFrontiers in medicine · 2023Article
- Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study.Frontiers in medicine · 2023Article
- TTV and other anelloviruses: The astonishingly wide spread of a viral infection.Aspects of molecular medicine · 2023Review
- Article
- Metagenomic sequencing reveals time, host, and body compartment-specific viral dynamics after lung transplantation.Microbiome · 2022Article
- Obesity is associated with a higher Torque Teno viral load compared to leanness.Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TT virus (TTV) is a recently identified widespread DNA virus of humans that produces persistent viremia in the absence of overt clinical manifestations. In an attempt to shed light on the dynamics of chronic infection, we measured the levels of TTV in the plasma of 25 persistently infected patients during the first 3 months of alpha interferon (IFN-alpha) treatment for concomitant hepatitis C virus (HCV) infection. The first significant decline of TTV loads was observed at day 3 versus day 1 for HCV. Subsequently, the loads of TTV became progressively lower in most patients, but some initial responders relapsed before the end of the follow-up, suggesting that at least in some subjects the effects of IFN on TTV can be very short-lived. No correlation between the responses of TTV and HCV to therapy was found. Fitting the viremia data obtained during the first week of treatment into previously developed mathematical models showed that TTV sustains very active chronic infections, with over 90% of the virions in plasma cleared and replenished daily and a minimum of approximately 3.8 x 10(10) virions generated per day. Low levels of TTV were occasionally detected in the peripheral blood mononuclear cells of patients who had cleared plasma viremia, thus corroborating previous results showing that these cells may support TTV replication and/or persistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.