ArticleThe Journal of physiology2001
Retrograde modulation of transmitter release by postsynaptic subtype 1 metabotropic glutamate receptors in the rat cerebellum.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Energetic and thermodynamical aspects of the cyclodextrins-cannabidiol complex in aqueous solution: a molecular-dynamics study.European biophysics journal : EBJ · 2020Article
- A new signalling pathway for parallel fibre presynaptic type 4 metabotropic glutamate receptors (mGluR4) in the rat cerebellar cortex.The Journal of physiology · 2012Article
- Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Vesicular glutamate transporters: spatio-temporal plasticity following hearing loss.Neuroscience · 2011Article
- Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- NMDA receptor contribution to the climbing fiber response in the adult mouse Purkinje cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Properties of persistent postnatal cortical subplate neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Differential control of two forms of glutamate release by group III metabotropic glutamate receptors at rat entorhinal synapses.Neuroscience · 2007Article
- Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Endocannabinoid signaling depends on the spatial pattern of synapse activation.Nature neuroscience · 2005Article
- Correlation of non-uniform protein expression with variation in transmitter release probability.Synapse (New York, N.Y.) · 2005Article
- Group I metabotropic glutamate receptors inhibit GABA release at interneuron-Purkinje cell synapses through endocannabinoid production.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Endocannabinoid-mediated short-term synaptic plasticity: depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE).British journal of pharmacology · 2004Review
- Synapses between parallel fibres and stellate cells express long-term changes in synaptic efficacy in rat cerebellum.The Journal of physiology · 2004Article
- Immunohistochemical localization of cannabinoid CB1 receptor in inhibitory interneurons in the cerebellum.Cerebellum (London, England) · 2004Article
- Interactions between adenosine and metabotropic glutamate receptors in the rat hippocampal slice.British journal of pharmacology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The aim of the study was to elucidate the mechanisms underlying the depressant effect of the group I/II metabotropic glutamate receptor (mGluR) agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) on parallel fibre (PF) to Purkinje cell (PC) synaptic transmission. Experiments were performed in rat cerebellar slices using the whole-cell patch-clamp technique and fluorometric measurements of presynaptic calcium variation 2. Analysis of short-term plasticity, fluctuation of EPSC amplitude and responses of PCs to exogenous glutamate showed that depression caused by 1S,3R-ACPD is presynaptic. 3. The effects of 1S,3R-ACPD were blocked and reproduced by group I mGluR antagonists and agonists, respectively. 4. These effects remained unchanged in mGluR5 knock-out mice and disappeared in mGluR1 knock-out mice. 5. 1S,3R-ACPD increased calcium concentration in PFs. This effect was abolished by AMPA/kainate (but not NMDA) receptor antagonists and mimicked by focally applied agonists of these receptors. Thus, it is not directly due to mGluRs but to presynaptic AMPA/kainate receptors indirectly activated by 1S,3R-ACPD. 6. Frequencies of spontaneous and evoked unitary EPSCs recorded in PCs were respectively increased and decreased by mGluR1 agonists. Similar results were obtained when mGluR1s were activated by tetanic stimulation of PFs. 7. Injecting 30 mM BAPTA into PCs blocked the effects of 1S,3R-ACPD on unitary EPSCs. 8. In conclusion, 1S,3R-ACPD reduces evoked release of glutamate from PFs. This effect is triggered by postsynaptic mGluR1s and thus implies that a retrograde messenger, probably glutamate, opens presynaptic AMPA/kainate receptors and consequently increases spontaneous release of glutamate from PF terminals and decreases evoked synaptic transmission.
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