ArticleGenes & development2001
TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Proteomic analysis of embryonic kidney development: Heterochromatin proteins as epigenetic regulators of nephrogenesis.Scientific reports · 2015Article
- Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion.Molecular oncology · 2015Article
- Dynamic changes in ribosome-associated proteome and phosphoproteome during deoxynivalenol-induced translation inhibition and ribotoxic stress.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation.Nucleic acids research · 2014Article
- The transcription intermediary factor 1β coactivates the androgen receptor.Journal of endocrinological investigation · 2013Article
- Clinical utility of KAP-1 expression in thyroid lesions.Endocrine pathology · 2013Article
- Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage.Toxicology and applied pharmacology · 2013Article
- KAP1 protein: an enigmatic master regulator of the genome.The Journal of biological chemistry · 2011Review
Corrections and comments
- Retraction · 2002-08-15Falsification/Fabrication of Image · Investigation by ORI · Investigation by Third Party · Misconduct by Author · Results Not Reproducible · · John Rooney has finding of misconduct https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259648/
- Commented on by
- RetractedRetraction.2002
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Representational difference analysis (RDA) cloning has identified transcriptional intermediary factor 1 beta (TIF1beta) as a gene inducibly expressed early during myeloid differentiation of the promyelocytic cell lines HL-60 and U937. To assess the role of TIF1beta, U937 cell lines were made that expressed antisense-hammerhead ribozymes targeted specifically against TIF1beta mRNA. These cells failed to differentiate into macrophages, as determined by several criteria: a nonadherent morphology, a failure to arrest cell cycle, lowered levels of macrophage-specific cell surface markers, resistance to Legionella pneumophila infection, a loss of the ability to phagocytose and chemotax, and decreased expression of chemokine mRNAs. One way TIF1beta acts in macrophage differentiation is to augment C/EBPbeta transcriptional activity. Furthermore, we show by EMSA supershifts and coimmunoprecipitation that C/EBPbeta and TIF1beta physically interact. Although TIF1beta is necessary for macrophage differentiation of U937 cells, it is not sufficient, based on the inability of ectopically expressed TIF1beta to induce or augment phorbol ester-induced macrophage differentiation. We conclude that TIF1beta plays an important role in the terminal differentiation program of macrophages, which involves the coactivation of C/EBPbeta and induction of C/EBPbeta-responsive myeloid genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.