ArticleGenes & development2001
Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
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- The Multifaceted Roles of RCC1 in Tumorigenesis.Frontiers in molecular biosciences · 2020Review
- The RNA Polymerase II Core Promoter inGenetics · 2019Review
- Systematic interrogation of human promoters.Genome research · 2019Article
- The Role of GC-Rich Sequences from the Promoter Region of the Drosophila melanogaster yellow Gene in the Enhancer- Dependent Activation of Transcription.Doklady. Biochemistry and biophysics · 2018Article
- A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.The Journal of biological chemistry · 2017Article
- The punctilious RNA polymerase II core promoter.Genes & development · 2017Review
- Methylation-silencing RCC1 expression is associated with tumorigenesis and depth of invasion in gastric cancer.International journal of clinical and experimental pathology · 2015Article
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- A new paradigm for transcription factor TFIIB functionality.Scientific reports · 2014Article
- Novel core promoter elements and a cognate transcription factor in the divergent unicellular eukaryote Trichomonas vaginalis.Molecular and cellular biology · 2011Article
- Improved Tet-responsive promoters with minimized background expression.BMC biotechnology · 2010Article
- Regulation of gene expression via the core promoter and the basal transcriptional machinery.Developmental biology · 2010Review
- Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells.Genome biology · 2010Article
- TFIIB recognition elements control the TFIIA-NC2 axis in transcriptional regulation.Molecular and cellular biology · 2009Article
- Caudal, a key developmental regulator, is a DPE-specific transcriptional factor.Genes & development · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB-recognition element (BRE), present in many promoters. Here we show that the BRE suppresses the basal level of transcription elicited by a core promoter, which increases the amplitude of transcriptional stimulation in the presence of an activator protein. Further, we find that an activator can disrupt the TFIIB-BRE interaction within a promoter-bound complex. Our results reveal a novel function for activators in the modulation of core promoter recognition by TFIIB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.