ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2001
Peripheral clocks and their role in circadian timing: insights from insects.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 114 citations in OpenAlex.
- Diel emergence and dispersal rhythms in the bamboo borer Dinoderus minutus (Coleoptera: Bostrichidae).Die Naturwissenschaften · 2026Article
- Time-of-day changes in permethrin susceptibility and metabolic gene expression in Florida Aedes aegypti (Diptera: Culicidae).Journal of medical entomology · 2025Article
- Males of Aedes aegypti show different clock gene expression profiles in the presence of conspecific females.Parasites & vectors · 2022Article
- Integration of Circadian Clock Information in theJournal of biological rhythms · 2021Review
- Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020Review
- Article
- The impact of artificial light at night on nocturnal insects: A review and synthesis.Ecology and evolution · 2018Review
- Circadian regulation of metabolism and healthspan in Drosophila.Free radical biology & medicine · 2018Review
- Circadian clock and oral cancer.Molecular and clinical oncology · 2018Article
- The role of the circadian clock system in physiology.Pflugers Archiv : European journal of physiology · 2018Review
- Age-Related Changes in the Expression of the Circadian Clock Protein PERIOD inFrontiers in physiology · 2017Article
- Ageing and Circadian rhythms.Current opinion in insect science · 2015Article
- In vitro and ex vivo models indicate that the molecular clock in fast skeletal muscle of Atlantic cod is not autonomous.Molecular biology reports · 2014Article
- Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging.International journal of molecular sciences · 2013Article
- Article
- Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Circadian plasticity in photoreceptor cells controls visual coding efficiency in Drosophila melanogaster.PloS one · 2010Article
- Metabolism control by the circadian clock and vice versa.Nature structural & molecular biology · 2009Article
- The Drosophila melanogaster circadian pacemaker circuit.Journal of genetics · 2008Review
- Circadian regulation of response to oxidative stress in Drosophila melanogaster.Biochemical and biophysical research communications · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impressive advances have been made recently in our understanding of the molecular basis of the cell-autonomous circadian feedback loop; however, much less is known about the overall organization of the circadian systems. How many clocks tick in a multicellular animal, such as an insect, and what are their roles and the relationships between them? Most attempts to locate clock-containing tissues were based on the analysis of behavioural rhythms and identified brain-located timing centres in a variety of animals. Characterization of several essential clock genes and analysis of their expression patterns revealed that molecular components of the clock are active not only in the brain, but also in many peripheral organs of Drosophila and other insects as well as in vertebrates. Subsequent experiments have shown that isolated peripheral organs can maintain self-sustained and light sensitive cycling of clock genes in vitro. This, together with earlier demonstrations that physiological output rhythms persist in isolated organs and tissues, provide strong evidence for the existence of functionally autonomous local circadian clocks in insects and other animals. Circadian systems in complex animals may include many peripheral clocks with tissue-specific functions and a varying degree of autonomy, which seems to be correlated with their sensitivity to external entraining signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.