ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2001
Flies, clocks and evolution.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Evolutionary divergence of core and post-translational circadian clock genes in the pitcher-plant mosquito, Wyeomyia smithii.BMC genomics · 2015Article
- Of Fighting Flies, Mice, and Men: Are Some of the Molecular and Neuronal Mechanisms of Aggression Universal in the Animal Kingdom?PLoS genetics · 2015Review
- Article
- Conservation of gene function in behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Sleep homeostasis: Progress at a snail's pace.Communicative & integrative biology · 2011Article
- Article
- Direct transcriptional control of a p38 MAPK pathway by the circadian clock in Neurospora crassa.PloS one · 2011Article
- A latitudinal cline in the Chinook salmon (Oncorhynchus tshawytscha) Clock gene: evidence for selection on PolyQ length variants.Proceedings. Biological sciences · 2008Article
- Evolutionary analysis of PHLPP1 gene in humans and non-human primates.Bioinformation · 2008Article
- Molecular and phylogenetic analyses reveal mammalian-like clockwork in the honey bee (Apis mellifera) and shed new light on the molecular evolution of the circadian clock.Genome research · 2006Article
- Evolution of temporal order in living organisms.Journal of circadian rhythms · 2005Article
- Article
- Cellular signalling and the complexity of biological timing: insights from the ultradian clock of Schizosaccharomyces pombe.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Peripheral clocks and their role in circadian timing: insights from insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Downloading central clock information in Drosophila.Molecular neurobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The negative feedback model for gene regulation of the circadian mechanism is described for the fruitfly, Drosophila melanogaster. The conservation of function of clock molecules is illustrated by comparison with the mammalian circadian system, and the apparent swapping of roles between various canonical clock gene components is highlighted. The role of clock gene duplications and divergence of function is introduced via the timeless gene. The impressive similarities in clock gene regulation between flies and mammals could suggest that variation between more closely related species within insects might be minimal. However, this is not borne out because the expression of clock molecules in the brain of the giant silk moth, Antheraea pernyi, is not easy to reconcile with the negative feedback roles of the period and timeless genes. Variation in clock gene sequences between and within fly species is examined and the role of co-evolution between and within clock molecules is described, particularly with reference to adaptive functions of the circadian phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.