ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2001
Genetic interactions between clock mutations in Neurospora crassa: can they help us to understand complexity?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- A global search for novel transcription factors impacting the Neurospora crassa circadian clock.G3 (Bethesda, Md.) · 2021Article
- The genetics of circadian rhythms in Neurospora.Advances in genetics · 2011Review
- Circadian rhythms in Neurospora crassa: clock mutant effects in the absence of a frq-based oscillator.Genetics · 2007Article
- Diversity of zebrafish peripheral oscillators revealed by luciferase reporting.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Circadian clock genes frequency and white collar-1 are not essential for entrainment to temperature cycles in Neurospora crassa.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Multiple oscillators regulate circadian gene expression in Neurospora.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The Neurospora circadian clock: simple or complex?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Cellular signalling and the complexity of biological timing: insights from the ultradian clock of Schizosaccharomyces pombe.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Recent work on circadian clocks in Neurospora has primarily focused on the frequency (frq) and white-collar (wc) loci. However, a number of other genes are known that affect either the period or temperature compensation of the rhythm. These include the period (no relationship to the period gene of Drosophila) genes and a number of genes that affect cellular metabolism. How these other loci fit into the circadian system is not known, and metabolic effects on the clock are typically not considered in single-oscillator models. Recent evidence has pointed to multiple oscillators in Neurospora, at least one of which is predicted to incorporate metabolic processes. Here, the Neurospora clock-affecting mutations will be reviewed and their genetic interactions discussed in the context of a more complex clock model involving two coupled oscillators: a FRQ/WC-based oscillator and a 'frq-less' oscillator that may involve metabolic components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.