ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2001
The Neurospora circadian clock: simple or complex?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Identification of Circadian Clock Homologs and Their Rhythmic Expression Differences Among Mating-Type Strains inJournal of fungi (Basel, Switzerland) · 2026Article
- A circadian clock in a nonphotosynthetic prokaryote.Science advances · 2021Article
- Habitat-Specific Clock Variation and Its Consequence on Reproductive Fitness.Journal of biological rhythms · 2020Article
- Natural Variation of the Circadian Clock in Neurospora.Advances in genetics · 2017Review
- Article
- Skin, reactive oxygen species, and circadian clocks.Antioxidants & redox signaling · 2014Review
- Circadian rhythm connections to oxidative stress: implications for human health.Antioxidants & redox signaling · 2013Review
- Consistent robustness analysis (CRA) identifies biologically relevant properties of regulatory network models.PloS one · 2010Article
- Intrinsic noise and division cycle effects on an abstract biological oscillator.Chaos (Woodbury, N.Y.) · 2010Article
- Robustness from flexibility in the fungal circadian clock.BMC systems biology · 2010Article
- Circadian rhythms in Neurospora crassa: dynamics of the clock component frequency visualized using a fluorescent reporter.Fungal genetics and biology : FG & B · 2010Article
- A developmental cycle masks output from the circadian oscillator under conditions of choline deficiency in Neurospora.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- Circadian clock genes frequency and white collar-1 are not essential for entrainment to temperature cycles in Neurospora crassa.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.Microbiology and molecular biology reviews : MMBR · 2004Review
- Distinct signaling pathways from the circadian clock participate in regulation of rhythmic conidiospore development in Neurospora crassa.Eukaryotic cell · 2002Article
- Genetic interactions between clock mutations in Neurospora crassa: can they help us to understand complexity?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Cellular signalling and the complexity of biological timing: insights from the ultradian clock of Schizosaccharomyces pombe.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Rhythms of differentiation and diacylglycerol in Neurospora.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
Abstract
The fungus Neurospora crassa is being used by a number of research groups as a model organism to investigate circadian (daily) rhythmicity. In this review we concentrate on recent work relating to the complexity of the circadian system in this organism. We discuss: the advantages of Neurospora as a model system for clock studies; the frequency (frq), white collar-1 and white collar-2 genes and their roles in rhythmicity; the phenomenon of rhythmicity in null frq mutants and its implications for clock mechanisms; the study of output pathways using clock-controlled genes; other rhythms in fungi; mathematical modelling of the Neurospora circadian system; and the application of new technologies to the study of Neurospora rhythmicity. We conclude that there may be many gene products involved in the clock mechanism, there may be multiple interacting oscillators comprising the clock mechanism, there may be feedback from output pathways onto the oscillator(s) and from the oscillator(s) onto input pathways, and there may be several independent clocks coexisting in one organism. Thus even a relatively simple lower eukaryote can be used to address questions about a complex, networked circadian system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.