ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2001
Circadian systems: different levels of complexity.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed.
- Bioluminescence and Photoreception in Unicellular Organisms: Light-Signalling in a Bio-Communication Perspective.International journal of molecular sciences · 2021Review
- Temperature-sensitive and circadian oscillators of Neurospora crassa share components.Genetics · 2012Article
- Clocks in the green lineage: comparative functional analysis of the circadian architecture of the picoeukaryote ostreococcus.The Plant cell · 2009Article
- Synergy between the light-induced acute response and the circadian cycle: a new mechanism for the synchronization of the Phaseolus vulgaris clock to light.Plant molecular biology · 2006Article
- Experimental determination of the periodicity of incremental features in enamel.Journal of anatomy · 2006Article
- Circuit topology and the evolution of robustness in two-gene circadian oscillators.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Article
- Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice.Genes & development · 2003Article
- The Neurospora circadian clock: simple or complex?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Cellular signalling and the complexity of biological timing: insights from the ultradian clock of Schizosaccharomyces pombe.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Genetic interactions between clock mutations in Neurospora crassa: can they help us to understand complexity?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Picking out parallels: plant circadian clocks in context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Flies, clocks and evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After approximately 50 years of circadian research, especially in selected circadian model systems (Drosophila, Neurospora, Gonyaulax and, more recently, cyanobacteria and mammals), we appreciate the enormous complexity of the circadian programme in organisms and cells, as well as in physiological and molecular circuits. Many of our insights into this complexity stem from experimental reductionism that goes as far as testing the interaction of molecular clock components in heterologous systems or in vitro. The results of this enormous endeavour show circadian systems that involve several oscillators, multiple input pathways and feedback loops that contribute to specific circadian qualities but not necessarily to the generation of circadian rhythmicity. For a full appreciation of the circadian programme, the results from different levels of the system eventually have to be put into the context of the organism as a whole and its specific temporal environment. This review summarizes some of the complexities found at the level of organisms, cells and molecules, and highlights similar strategies that apparently solve similar problems at the different levels of the circadian system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.