ArticleOncogene2001
Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements.Genome research · 2023Article
- Quantitative Approaches to Study Retinal Neurogenesis.Biomedicines · 2021Review
- The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming.Cell reports · 2019Article
- P2YMolecular neurobiology · 2018Article
- Age-dependent dormant resident progenitors are stimulated by injury to regenerate Purkinje neurons.eLife · 2018Article
- Interplay between p53 and Ink4c in spermatogenesis and fertility.Cell cycle (Georgetown, Tex.) · 2018Article
- Microglia increases the proliferation of retinal precursor cells during postnatal development.Molecular vision · 2018Article
- Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study.BMC ophthalmology · 2017Article
- p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells.Molecular and cellular biology · 2016Article
- Coordinating progenitor cell cycle exit and differentiation in the developing vertebrate retina.Neurogenesis (Austin, Tex.) · 2016Article
- KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.PLoS genetics · 2015Article
- Novel endogenous glycan therapy for retinal diseases: safety, in vitro stability, ocular pharmacokinetic modeling, and biodistribution.The AAPS journal · 2014Article
- Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Pax6 is required for normal cell-cycle exit and the differentiation kinetics of retinal progenitor cells.PloS one · 2013Article
- G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Temporally distinct roles for tumor suppressor pathways in cell cycle arrest and cellular senescence in Cyclin D1-driven tumor.Molecular cancer · 2012Article
- Retinal horizontal cells: challenging paradigms of neural development and cancer biology.Development (Cambridge, England) · 2009Review
- Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells.Neural development · 2009Article
- CD133+ adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF).BMC ophthalmology · 2009Article
- p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor.Cancer research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differentiation of neuronal cells in the developing mammalian retina is closely coupled to cell cycle arrest and proceeds in a highly organized manner. Cyclin D1, which regulates cell proliferation in many cells, also drives the proliferation of photoreceptor progenitors. In the mouse retina, cyclin D1 protein normally decreases as photoreceptors mature. To study the importance of the down-regulation of cyclin D1 during photoreceptor development, we generated a transgenic mouse in which cyclin D1 was persistently expressed in developing photoreceptor cells. We observed numerous abnormalities in both photoreceptors and other nonphotoreceptor cells in the retina of these transgenic mice. In particular, we observed delayed opsin expression in developing photoreceptors and alterations in their number and morphology in the mature retina. These alterations were accompanied by disorganization of the inner nuclear and plexiform layers. The expression of cyclin D1 caused excess photoreceptor cell proliferation and apoptosis. Loss of the p53 tumor suppressor gene decreased cyclin D1-induced apoptosis and led to microscopic hyperplasia in the retina. These findings are distinct from other mouse models in which the retinoblastoma gene pathway is disrupted and suggest that the IRBP-cyclin D1 mouse model may recapitulate an early step in the development of retinoblastoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.