Evidence map›Paper›PMID 11709705›Full record

ArticleOncogene2001

LAPSER1: a novel candidate tumor suppressor gene from 10q24.3.

Y Cabeza-Arvelaiz, T C Thompson, J L Sepulveda, A C Chinault

Abstract read
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In one paragraph

Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Y Cabeza-ArvelaizDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
T C Thompson
J L Sepulveda
A C Chinault
Baylor College of Medicine · USUniversity of Pittsburgh · US

Funding

STEROID RECEPTORS SUPERFAMILY MEMBERS--THEIR ROLE IN PROSTATE CANCERP50CA058204 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ITTMANN, MICHAEL M. · 1992 to 2007
$21.3M
NCI NIH HHS P50-CA58204
6 · The paper itself

Abstract

Numerous LOH and mutation analysis studies in different tumor tissues, including prostate, indicate that there are multiple tumor suppressor genes (TSGs) present within the human chromosome 8p21-22 and 10q23-24 regions. Recently, we showed that LZTS1 (or FEZ1), a putative TSG located on 8p22, has the potential to function as a cell growth modulator. We report here the cloning, gene organization, cDNA sequence characterization and expression analysis of LAPSER1, an LZTS1-related gene. This gene maps within a subregion of human chromosome 10q24.3 that has been reported to be deleted in various cancers, including prostate tumors, as frequently as the neighboring PTEN locus. The complete LAPSER1 cDNA sequence encodes a predicted protein containing various domains resembling those typically found in transcription factors (P-Box, Q-rich and multiple leucine zippers). LAPSER1 is expressed at the highest levels in normal prostate and testis, where multiple isoforms are seen, some of which are either undetectable or differentially expressed in some prostate tumor tissues and cell lines. Over-expression of LAPSER1 cDNA strongly inhibited cell growth and colony-forming efficiencies of most cancer cells assessed. Together these data suggest that LAPSER1 is another gene involved in the regulation of cell growth whose loss of function may contribute to the development of cancer.

Indexed as

Chromosomes, Human, Pair 10Genes, Tumor SuppressorTumor Suppressor ProteinsAmino Acid SequenceAnimalsBlotting, NorthernCell Cycle ProteinsCell DivisionCell LineChromosome MappingCloning, MolecularDatabases as TopicDNA-Binding ProteinsDNA, ComplementaryDNA Mutational AnalysisGene DeletionCell Cycle ProteinsDNA-Binding ProteinsDNA, ComplementaryLZTS2 protein, humanTumor Suppressor Proteins

Identifiers

PMID11709705
OpenAlexW2322090726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.