ArticleAnnals of the rheumatic diseases2001
Detection of immune deposits in skin lesions of patients with Wegener's granulomatosis.
Article in Annals of the rheumatic diseases, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 71 citations in OpenAlex.
- Cryptococcoid Sweet syndrome: a case report.Frontiers in medicine · 2024Article
- Article
- Mechanisms of vascular damage in ANCA vasculitis.Seminars in immunopathology · 2022Review
- Glomerular Immune Deposition in MPO-ANCA Associated Glomerulonephritis Is Associated With Poor Renal Survival.Frontiers in immunology · 2021Article
- Clinicopathologic correlation of 282 leukocytoclastic vasculitis cases in a tertiary hospital: a focus on direct immunofluorescence findings at the blood vessel wall.Immunologic research · 2017Article
- Review
- Linking classification and therapeutic management of vasculitides.Arthritis research & therapy · 2015Review
- [Vasculitis: New nomenclature of the Chapel Hill consensus conference 2012].Zeitschrift fur Rheumatologie · 2014Article
- [Vasculitis. New nomenclature of the Chapel Hill consensus conference 2012].Der Pathologe · 2013Review
- Pathogenesis of ANCA-associated vasculitis.Current rheumatology reports · 2012Review
- Antineutrophil cytoplasmic autoantibodies: how are they detected and what is their use for diagnosis, classification and follow-up?Clinical reviews in allergy & immunology · 2012Review
- Immune deposits in cutaneous lesions of Wegener's granulomatosis: predictor of an active disease.Indian journal of dermatology · 2011Article
- Fulminant primary manifestations of Wegener's granulomatosis might not be pauci-immune.NDT plus · 2010Article
- Pathogenesis of ANCA-associated vasculitis.Rheumatic diseases clinics of North America · 2010Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWegener's granulomatosis (WG) is considered a pauci-immune systemic vasculitis based on the absence of immune deposits in renal biopsies of patients with active disease. In animal models of antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis, immune deposits along the glomerular capillary wall are present at early stages of lesion development. These deposits are degraded rapidly, resulting in "pauci-immune" lesions.
objectiveTo test the hypothesis that immune deposits can also be detected in early lesions of patients with WG, thereby initiating an inflammatory reaction that, in time, is augmented in the presence of ANCA, resulting in pauci-immune lesions later on.
methodsThe presence of immune deposits in skin biopsies taken within 48 hours of lesion development was investigated. Direct immunofluorescence was used to examine 32 skin biopsies for the presence of immune deposits (IgG, IgA, IgM, C3c). When possible, a comparison was made between the immunofluorescence findings in renal and skin biopsies taken at the same time.
resultsFour of 11 biopsies taken at initial presentation and four of 21 biopsies taken at the onset of a relapse of WG showed IgG and/or IgA containing immune deposits in the subepidermal blood vessels. All nine renal biopsies showed pauci-immune glomerulonephritis, irrespective of the presence (n=5) or absence (n=4) of immune deposits in the skin biopsy.
conclusionA substantial number of skin biopsies showed immune deposits during active disease. These results could support the hypothesis that immune complexes may trigger vasculitic lesions in WG.
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