ArticleAntimicrobial agents and chemotherapy2001
A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron.
Article in Antimicrobial agents and chemotherapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 117 citations in OpenAlex.
- Article
- Fifty years devoted to anaerobes: historical, lessons, and highlights.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Review
- Contribution and expression of renal drug transporters in renal cell carcinoma.Frontiers in pharmacology · 2024Review
- Review
- Global Antimicrobial Resistance Gene Study ofAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Time for Some Group Therapy: Update on Identification, Antimicrobial Resistance, Taxonomy, and Clinical Significance of the Bacteroides fragilis Group.Journal of clinical microbiology · 2022Review
- HumanFrontiers in cellular and infection microbiology · 2022Article
- Drug resistance: from bacteria to cancer.Molecular biomedicine · 2021Review
- Genomic Background and Phylogeny ofAntibiotics (Basel, Switzerland) · 2021Article
- Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments.Cell reports · 2021Article
- Higher Prevalence of Multi-Antimicrobial ResistantInfection and drug resistance · 2020Article
- Functional signature analysis of extreme Prakriti endophenotypes in gut microbiome of western Indian rural population.Bioinformation · 2019Article
- Global analysis of the MATE gene family of metabolite transporters in tomato.BMC plant biology · 2017Article
- Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.Cold Spring Harbor perspectives in medicine · 2016Review
- Genome-wide analysis of MATE transporters and expression patterns of a subgroup of MATE genes in response to aluminum toxicity in soybean.BMC genomics · 2016Article
- Drug Resistance Mechanisms in Bacteria Causing Sexually Transmitted Diseases and Associated with Vaginosis.Frontiers in microbiology · 2016Review
- Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications.Channels (Austin, Tex.) · 2016Review
- Mechanisms of drug resistance: quinolone resistance.Annals of the New York Academy of Sciences · 2015Review
- Structural basis for the blockade of MATE multidrug efflux pumps.Nature communications · 2015Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
We cloned a gene, bexA, that codes for a multidrug efflux transporter from the chromosomal DNA of Bacteroides thetaiotaomicron ATCC 29741 by using an Escherichia coli DeltaacrAB DeltaacrEF mutant as a host. Although the initial recombinant construct contained other open reading frames, the presence of bexA alone was sufficient to confer to the E. coli host elevated levels of resistance to norfloxacin, ciprofloxacin, and ethidium bromide. Disruption of bexA in B. thetaiotaomicron made the strain more susceptible to norfloxacin, ciprofloxacin, and ethidium bromide, showing that this gene is expressed in this organism and functions as a multidrug efflux pump. The deduced BexA protein sequence was homologous to the protein sequence of Vibrio parahaemolyticus NorM, a multidrug efflux transporter, and thus, BexA belongs to the multidrug and toxic compound extrusion (MATE) family.
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