Evidence map›Paper›PMID 11708399›Full record

ReviewSports medicine (Auckland, N.Z.)2001

Antioxidants in exercise nutrition.

C K Sen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

C K SenDepartment of Surgery and Molecular and Cellular Biochemistry, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus 43210, USA. sen-1@medctr.osu.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical exercise may be associated with a 10- to 20-fold increase in whole body oxygen uptake. Oxygen flux in the active peripheral skeletal muscle fibres may increase by as much as 100- to 200-fold during exercise. Studies during the past 2 decades suggest that during strenuous exercise, generation of reactive oxygen species (ROS) is elevated to a level that overwhelms tissue antioxidant defence systems. The result is oxidative stress. The magnitude of the stress depends on the ability of the tissues to detoxify ROS, that is, antioxidant defences. Antioxidants produced by the body act in concert with their exogenous, mainly dietary, counterparts to provide protection against the ravages of reactive oxygen as well as nitrogen species. Antioxidant supplementation is likely to provide beneficial effects against exercise-induced oxidative tissue damage. While universal recommendations specifying types and dosages of antioxidants are difficult to make, it would be prudent for competitive athletes routinely engaged in strenuous exercise to seek an estimate of individual requirement. A new dimension in oxidant biology has recently unfolded. Although excessive oxidants may cause damage to tissues, lower levels of oxidants in biological cells may act as messenger molecules enabling the function of numerous physiological processes. It is plausible that some exercise-induced beneficial effects are actually oxidant-mediated. Such developments call for an even more careful analysis of the overall significance of types and amounts of antioxidants in diet. While these complexities pose significant challenges, experts agree that if used prudently, oxidants and antioxidants may serve as potent therapeutic tools. Efforts to determine individual needs of athletes and a balanced diet rich in antioxidant supplements are highly recommended.

Indexed as

AnimalsAntioxidantsAscorbic AcidDietary SupplementsExerciseHumansLipid PeroxidationOxidative StressReactive Oxygen SpeciesTocopherolsAntioxidantsAscorbic AcidReactive Oxygen SpeciesTocopherols

Identifiers

PMID11708399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.