ArticleThe EMBO journal2001
Apparent genetic redundancy facilitates ecological plasticity for nitrate transport.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 88 citations in OpenAlex.
- Article
- Hyphae of the fungus Aspergillus nidulans demonstrate chemotropism to nutrients and pH.PLoS biology · 2024Article
- Characterization of the promoter of the nitrate transporter-encoding gene nrtA in Aspergillus nidulans.Molecular genetics and genomics : MGG · 2020Article
- CaNRT2.1 Is Required for Nitrate but Not Nitrite Uptake in Chili Pepper PathogenFrontiers in microbiology · 2020Article
- Nitrate assimilation pathway (NAP): role of structural (nit) and transporter (ntr1) genes in Fusarium oxysporum f.sp. lycopersici growth and pathogenicity.Current genetics · 2018Article
- Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.Genome biology · 2017Article
- Nitrate Assimilation inFrontiers in microbiology · 2017Article
- Characterization of gprK Encoding a Putative Hybrid G-Protein-Coupled Receptor in Aspergillus fumigatus.PloS one · 2016Article
- High-affinity nitrate/nitrite transporters NrtA and NrtB of Aspergillus nidulans exhibit high specificity and different inhibitor sensitivity.Microbiology (Reading, England) · 2015Article
- Chrysanthemum CmNAR2 interacts with CmNRT2 in the control of nitrate uptake.Scientific reports · 2014Article
- Pseudo-constitutivity of nitrate-responsive genes in nitrate reductase mutants.Fungal genetics and biology : FG & B · 2013Article
- Trancriptional landscape of Aspergillus niger at breaking of conidial dormancy revealed by RNA-sequencing.BMC genomics · 2013Article
- Structure-function relationship of assimilatory nitrite reductases from the leaf and root of tobacco based on high-resolution structures.Protein science : a publication of the Protein Society · 2012Article
- Physiological and biochemical characterization of AnNitA, the Aspergillus nidulans high-affinity nitrite transporter.Eukaryotic cell · 2011Article
- Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism.Molecular microbiology · 2010Article
- Nuclear export of the transcription factor NirA is a regulatory checkpoint for nitrate induction in Aspergillus nidulans.Molecular and cellular biology · 2007Article
- Dissection of the AtNRT2.1:AtNRT2.2 inducible high-affinity nitrate transporter gene cluster.Plant physiology · 2007Article
- Characterization of a two-component high-affinity nitrate uptake system in Arabidopsis. Physiology and protein-protein interaction.Plant physiology · 2006Article
- High-affinity nitrate transport in roots of Arabidopsis depends on expression of the NAR2-like gene AtNRT3.1.Plant physiology · 2006Article
- Functional properties and differential mode of regulation of the nitrate transporter from a plant symbiotic ascomycete.The Biochemical journal · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus nidulans possesses two high-affinity nitrate transporters, encoded by the nrtA and the nrtB genes. Mutants expressing either gene grew normally on 1-10 mM nitrate as sole nitrogen source, whereas the double mutant failed to grow on nitrate concentrations up to 200 mM. These genes appear to be regulated coordinately in all growth conditions, growth stages and regulatory genetic backgrounds studied. Flux analysis of single gene mutants using 13NO3(-) revealed that K(m) values for the NrtA and NrtB transporters were approximately 100 and approximately 10 microM, respectively, while V(max) values, though variable according to age, were approximately 600 and approximately 100 nmol/mg dry weight/h, respectively, in young mycelia. This kinetic differentiation may provide the necessary physiological and ecological plasticity to acquire sufficient nitrate despite highly variable external concentrations. Our results suggest that genes involved in nitrate assimilation may be induced by extracellular sensing of ambient nitrate without obligatory entry into the cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.