ArticlePlant physiology2001
Functions of AKT1 and AKT2 potassium channels determined by studies of single and double mutants of Arabidopsis.
Article in Plant physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 124 citations in OpenAlex.
- Potassium Deficiency and Hormone Signalling in Plants.Plant, cell & environment · 2026Review
- Rhizosphere microbiomes in drought-tolerant and drought-sensitive bermudagrass genotypes: root exudate association.Frontiers in microbiology · 2026Article
- Shaker KTransgenic research · 2025Article
- Comparative Physiological and Gene Expression Analyses Reveal Mechanisms Involved in Maintaining Photosynthesis Capacity, Alleviating Ion Toxicity and Oxidative Stress of Kentucky Bluegrass under NaCl Treatment.Plants (Basel, Switzerland) · 2024Article
- Comparative physiological and transcriptome analysis between potassium-deficiency tolerant and sensitive sweetpotato genotypes in response to potassium-deficiency stress.BMC genomics · 2024Article
- Ionomic and metabolic responses of wheat seedlings to PEG-6000-simulated drought stress under two phosphorus levels.PloS one · 2022Article
- Article
- Feedback inhibition of AMT1 NHBMC biology · 2020Article
- Metabolomics Response for Drought Stress Tolerance in Chinese Wheat Genotypes (Plants (Basel, Switzerland) · 2020Article
- Identification of Shaker KPlanta · 2019Article
- Membrane proteome profiling of Mentha arvensis leaves in response to Alternaria alternata infection identifies crucial candidates for defense response.Plant signaling & behavior · 2018Article
- Metabolic responses to drought stress in the tissues of drought-tolerant and drought-sensitive wheat genotype seedlings.AoB PLANTS · 2018Article
- The Role of Potassium Channels in Arabidopsis thaliana Long Distance Electrical Signalling: AKT2 Modulates Tissue Excitability While GORK Shapes Action Potentials.International journal of molecular sciences · 2018Article
- Mapping the microRNA Expression Profiles in Glyoxalase Over-expressing Salinity Tolerant Rice.Current genomics · 2018Article
- Arbuscular Mycorrhizal FungusFrontiers in plant science · 2017Article
- NaScientific reports · 2016Article
- Diversification of fruit shape in the Brassicaceae family.Plant reproduction · 2016Review
- The AKT2 potassium channel mediates NaCl induced depolarization in the root of Arabidopsis thaliana.Plant signaling & behavior · 2016Article
- Article
- The Calcium Sensor CBL-CIPK Is Involved in Plant's Response to Abiotic Stresses.International journal of genomics · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A reverse genetic strategy was used to isolate Arabidopsis plants containing "knockout" mutations in AKT1 and AKT2, two members of a K+ channel gene family. Comparative studies of growth and membrane properties in wild-type and mutant seedlings were performed to investigate the physiological functions of these two related channels. The growth rates of plants supplied with rate-limiting concentrations of K+ depended on the presence of AKT1 but not AKT2 channels. This result indicates that AKT1 but not AKT2 mediates growth-sustaining uptake of K+ into roots, consistent with the expression patterns of these two genes. K+ -induced membrane depolarizations were measured with microelectrodes to assess the contribution each channel makes to the K+ permeability of the plasma membrane in three different organs. In apical root cells, AKT1 but not AKT2 contributed to the K+ permeability of the plasma membrane. In cotyledons, AKT1 was also the principal contributor to the K+ permeability. However, in the mesophyll cells of leaves, AKT2 accounted for approximately 50% of the K+ permeability, whereas AKT1 unexpectedly accounted for the remainder. The approximately equal contributions of AKT1 and AKT2 in leaves detected by the in vivo functional assay employed here are not in agreement with previous RNA blots and promoter activity studies, which showed AKT2 expression to be much higher than AKT1 expression in leaves. This work demonstrates that comparative functional studies of specific mutants can quantify the relative contributions of particular members of a gene family, and that expression studies alone may not reliably map out distribution of gene functions.
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Identifiers
11706182PMC129271W2168499060What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.