ArticleInfection and immunity2001
Blockade of caspases inhibits amebic liver abscess formation in a mouse model of disease.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Management of cell death in parasitic infections.Seminars in immunopathology · 2021Review
- Recent advances on innate immune pathways related to host-parasite cross-talk in cystic and alveolar echinococcosis.Parasites & vectors · 2020Review
- Apoptotic mimicry as a strategy for the establishment of parasitic infections: parasite- and host-derived phosphatidylserine as key molecule.Cell communication and signaling : CCS · 2020Review
- Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D.Mucosal immunology · 2019Article
- Article
- Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex-dependent manner in a mouse model of hepatocarcinogenesis.Alcoholism, clinical and experimental research · 2012Article
- Tissue destruction and invasion by Entamoeba histolytica.Trends in parasitology · 2011Review
- A Sequential Model of Host Cell Killing and Phagocytosis by Entamoeba histolytica.Journal of parasitology research · 2011Article
- Apoptosis induced by parasitic diseases.Parasites & vectors · 2010Article
- Epithelial cell apoptosis facilitates Entamoeba histolytica infection in the gut.The American journal of pathology · 2010Article
- Gender and genetic control of resistance to intestinal amebiasis in inbred mice.Genes and immunity · 2008Article
- Entamoeba histolytica phagocytosis of human erythrocytes involves PATMK, a member of the transmembrane kinase family.PLoS pathogens · 2008Article
- Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model.The Journal of experimental medicine · 2003Article
- Apoptotic killing and phagocytosis of host cells by the parasite Entamoeba histolytica.Infection and immunity · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We looked at the effect of inhibiting caspases on amebic liver abscess in the mouse model of infection. A dose of the pan-caspase inhibitor benzyloxycarbonyl-V-A-D-O-methyl fluoromethyl ketone (Z-VAD-FMK; R & D Systems) given to SCID mice 2 h prior to direct hepatic inoculation with Entamoeba histolytica trophozoites, and 12 h after amebic inoculation, reduced the mean liver abscess size by 70% at 24 h compared to a control group. These data indicate that apoptosis plays a significant but not an exclusive role in amebic liver abscess formation in the mouse model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.